Anthropology and Human Genetics

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LST1 and Functional Tunneling Nanotubes

We showed that LST1 induces functional tunneling nanotubes (TNT) in various cell types, which allow long distance communication between remote cells. High LST1 expression in antigen presenting cells indicates a role in the regulation of the immune response in tissues. We want to understand the formation and signal/cargo transfer of TNT and find tools for interference.