Anthropology and Human Genetics

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Human Molecular Genetics


Weidle UH, Tiefenthaler G, Weiss EH, Georges G, Brinkmann U. The intriguing options of multispecific antibody formats for treatment of cancer. Cancer Genomics Proteomics. 2013; 10: 1-18.

Varzari A, Kharkov V, Nikitin AG, Raicu F, Simonova K, Stephan W, Weiss EH, Stepanov V. Paleo-balkan and slavic contributions to the genetic pool of moldavians: insights from the y chromosome. PLoS One. 2013;8(1):e53731. doi: 10.1371/journal.pone.0053731. Epub 2013 Jan 16.

Schiller C, Diakopoulos KN, Rohwedder I, Kremmer E, von Toerne C, Ueffing M, Weidle UH, Ohno H, Weiss EH. LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation. J Cell Sci. 2012 Dec 13. 

Schiller C, Huber JE, Diakopoulos KN, Weiss EH. Tunneling nanotubes enable intercellular transfer of MHC class I molecules. Hum Immunol. 2013, 74: 412-6.


Molin S, Weiss EH, Ruzicka T, Messer G. The FAS/cd95 promoter single-nucleotide polymorphism -670 A/G and lupus erythematosus. Clin Exp Dermatol. 2012; 37: 425-7.


Fellerhoff B, Gu S, Laumbacher B, Nerlich AG, Weiss EH, Glas J, Kopp R, Johnson JP, Wank R. The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer. Cancer Res. 2011; 71: 7145-54.

Molin S, Vollmer S, Weiss EH, Weisenseel P, Ruzicka T, Prinz JC. Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis. J Investig Allergol Clin Immunol. 2011; 21: 472-9.

Weidle UH, Maisel D, Klostermann S, Weiss EH, Schmitt M. Differential splicing generates new transmembrane receptor and extracellular matrix-related targets for antibody-based therapy of cancer. Cancer Genomics Proteomics. 2011; 8: 211-26.

Weidle UH, Maisel D, Klostermann S, Schiller C, Weiss EH. Intracellular Proteins Displayed on the Surface of Tumor Cells as Targets for Therapeutic Intervention with Antibody-related Agents. Cancer Genomics Proteomics. 2011; 8: 49-63.


Schiller C, Nitschké MJ, Seidl A, Kremmer E, Weiss EH. Rat monoclonal antibodies specific for LST1 proteins. Hybridoma. 2009; 28: 281-6.

Molin S, Vollmer S, Weiss EH, Ruzicka T, Prinz JC. Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis. Br J Dermatol. 2009; 161: 801-7.

Kopp R, Glas J, Lau-Werner U, Albert ED, Weiss EH. Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer. J Clin Immunol. 2009; 29: 545-54.

Weiss EH, Lilienfeld BG, Müller S, Müller E, Herbach N, Kessler B, Wanke R, Schwinzer R, Seebach JD, Wolf E, Brem G. HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity. Transplantation. 2009; 87: 35-43.

Varzari A, Kharkov V, Stephan W, Dergachev V, Puzyrev V, Weiss EH, Stepanov V. Searching for the origin of Gagauzes: inferences from Y-chromosome analysis. Am J Hum Biol. 2009; 21: 326-36.

Sensi M, Pietra G, Molla A, Nicolini G, Vegetti C, Bersani I, Millo E, Weiss E, Moretta L, Mingari MC, Anichini A. Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5. Int Immunol. 2009; 21: 257-68


Glas J, Maier K, Wetzke M, Henninger M, Weiss EH, Folwaczny M. MICA*055: a new allele with eight GCT repeats in the exon 5 microsatellite. Tissue Antigens. 2008; 72:410-1.


Unterberger C, Hanson S, Klingenhoff A, Oesterle D, Frankenberger M, Endo Y, Matsushita M, Fujita T, Schwaeble W, Weiss EH, Ziegler-Heitbrock L, Stover C. Stat3 is involved in control of MASP2 gene expression. Biochem Biophys Res Commun. 2007; 364: 1022-5.

Glas J, Török HP, Tonenchi L, Wetzke M, Beynon V, Teshome MY, Cotofana S, Schiemann U, Griga T, Klein W, Epplen JT, Folwaczny C, Folwaczny M, Mussack T, Weiss EH. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. Int Immunol. 2007; 19: 621-6.

Varzari A, Stephan W, Stepanov V, Raicu F, Cojocaru R, Roschin Y, Glavce C, Dergachev V, Spiridonova M, Schmidt HD, Weiss E. Population history of the Dniester-Carpathians: evidence from Alu markers. J Hum Genet. 2007; 52: 308-16.

van der Meer A, Lukassen HG, van Cranenbroek B, Weiss EH, Braat DD, van Lierop MJ, Joosten I. Soluble HLA-G promotes Th1-type cytokine production by cytokine-activated uterine and peripheral natural killer cells. Mol Hum Reprod. 2007; 13: 123-33.


von Geldern M, Simm B, Braun M, Weiss EH, Schendel DJ, Falk CS. TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I. Eur J Immunol. 2006; 36: 2347-58.


Forte P, Baumann BC, Weiss EH, Seebach JD. HLA-E expression on porcine cells: protection from human NK cytotoxicity depends on peptide loading. Am J Transplant. 2005; 5: 2085-93.

Nattermann J, Nischalke HD, Hofmeister V, Kupfer B, Ahlenstiel G, Feldmann G, Rockstroh J, Weiss EH, Sauerbruch T, Spengler U. HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. Antivir Ther. 2005; 10: 95-107.

Nattermann J, Nischalke HD, Hofmeister V, Ahlenstiel G, Zimmermann H, Leifeld L, Weiss EH, Sauerbruch T, Spengler U. The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells. Am J Pathol. 2005; 166: 443-53.


Kuon W, Kuhne M, Busch DH, Atagunduz P, Seipel M, Wu P, Morawietz L, Fernahl G, Appel H, Weiss EH, Krenn V, Sieper J. Identification of novel human aggrecan T cell epitopes in HLA-B27 transgenic mice associated with spondyloarthropathy. J Immunol. 2004; 173: 4859-66.

Ulbrecht M, Maier S, Hofmeister V, Falk CS, Brooks AG, McMaster MT, Weiss EH. Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands. Hum Immunol. 2004; 65: 200-8.


Hofmeister V, Weiss EH. HLA-G modulates immune responses by diverse receptor interactions. Semin Cancer Biol. 2003; 13: 317-23.Review.

Polakova K, Bandzuchova E, Hofmeister V, Weiss EH, Hutter H, Russ G. Binding analysis of HLA-G specific antibodies to hematopoietic cells isolated from leukemia patients. Neoplasma. 2003; 50: 331-8.

Schleypen JS, Von Geldern M, Weiss EH, Kotzias N, Rohrmann K, Schendel DJ, Falk CS, Pohla H. Renal cell carcinoma-infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes. Int J Cancer. 2003; 106: 905-12.

Zendman AJ, Zschocke J, van Kraats AA, de Wit NJ, Kurpisz M, Weidle UH, Ruiter DJ, Weiss EH, van Muijen GN. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. Gene. 2003; 309: 125-33.

Ulbrecht M, Hofmeister V, Yuksekdag G, Ellwart JW, Hengel H, Momburg F, Martinozzi S, Reboul M, Pla M, Weiss EH. HCMV glycoprotein US6 mediated inhibition of TAP does not affect HLA-E dependent protection of K-562 cells from NK cell lysis. Hum Immunol. 2003; 64: 231-7.

Wiendl H, Mitsdoerffer M, Hofmeister V, Wischhusen J, Weiss EH, Dichgans J, Lochmuller H, Hohlfeld R, Melms A, Weller M. The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy. Brain. 2003; 126: 176-85.


Falk CS, Mach M, Schendel DJ, Weiss EH, Hilgert I, Hahn G. NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation. J Immunol. 2002; 169: 3257-66.

Wiendl H, Mitsdoerffer M, Hofmeister V, Wischhusen J, Bornemann A, Meyermann R, Weiss EH, Melms A, Weller M. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol. 2002; 168: 4772-80.

Rieger L, Hofmeister V, Probe C, Dietl J, Weiss EH, Steck T, Kammerer U. Th1- and Th2-like cytokine production by first trimester decidual large granular lymphocytes is influenced by HLA-G and HLA-E. Mol Hum Reprod. 2002; 8: 255-61.

Falk CS, Noessner E, Weiss EH, Schendel DJ. Retaliation against tumor cells showing aberrant HLA expression using lymphokine activated killer-derived T cells. Cancer Res. 2002; 62: 480-7.

Huarte E, Sarobe P, Lasarte JJ, Brem G, Weiss EH, Prieto J, Borras-Cuesta F. Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen. Int J Cancer. 2002; 97: 58-63.


Glas J, Martin K, Brunnler G, Kopp R, Folwaczny C, Weiss EH, Albert ED. MICA, MICB and C1_4_1 polymorphism in Crohn's disease and ulcerative colitis. Tissue Antigens. 2001; 58: 243-9.

Kuon W, Holzhutter HG, Appel H, Grolms M, Kollnberger S, Traeder A, Henklein P, Weiss E, Thiel A, Lauster R, Bowness P, Radbruch A, Kloetzel PM, Sieper J. Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases. J Immunol. 2001; 167: 4738-46.


Maier S, Grzeschik M, Weiss EH, Ulbrecht M. Implications of HLA-E allele expression and different HLA-E ligand diversity for the regulation of NK cells. Hum Immunol. 2000; 61: 1059-65.

Wiendl H, Behrens L, Maier S, Johnson MA, Weiss EH, Hohlfeld R. Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G. Ann Neurol. 2000; 48: 679-84.

Marget M, Sharma BB, Tesar M, Kretzschmar T, Jenisch S, Westphal E, Davarnia P, Weiss E, Ulbrecht M, Kabelitz D, Kronke M. Bypassing hybridoma technology: HLA-C reactive human single-chain antibody fragments (scFv) derived from a synthetic phage display library (HuCAL) and their potential to discriminate HLA class I specificities. Tissue Antigens. 2000; 56: 1-9.

Ulbrecht M, Martinozzi S, Grzeschik M, Hengel H, Ellwart JW, Pla M, Weiss EH. Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J Immunol. 2000; 164: 5019-22.

Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H. LST1: a gene with extensive alternative splicing and immunomodulatory function. J Immunol. 2000; 164: 3169-76.

Ulbrecht M, Hergeth MT, Wjst M, Heinrich J, Bickeboller H, Wichmann HE, Weiss EH. Association of beta(2)-adrenoreceptor variants with bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2000; 161: 469-74.

Linke RP, Schaeffer J, Gielow P, Lindner P, Lottspeich F, Pluckthun A, Weiss EH. Production of recombinant human beta2-microglobulin for scintigraphic diagnosis of amyloidosis in uremia and hemodialysis. Eur J Biochem. 2000; 267: 627-33.


Pacasova R, Martinozzi S, Boulouis HJ, Szpak Y, Ulbrecht M, Sigaux F, Weiss EH, Pla M. Cell surface detection of HLA-E gene products with a specific monoclonal antibody. J Reprod Immunol. 1999; 43: 195-201.

Boulouis HJ, Martinozzi S, Pacasova R, Piroird C, Vieville JC, Ulbrecht M, Sigaux F, Weiss EH, Pla M. Expression of HLA-E in transgenic mice. Transplant Proc. 1999; 31: 1868-70.

Maier S, Geraghty DE, Weiss EH. Expression and regulation of HLA-G in human glioma cell lines. Transplant Proc. 1999; 31: 1849-53.

Wjst M, Fischer G, Immervoll T, Jung M, Saar K, Rueschendorf F, Reis A, Ulbrecht M, Gomolka M, Weiss EH, Jaeger L, Nickel R, Richter K, Kjellman NI, Griese M, von Berg A, Gappa M, Riedel F, Boehle M, van Koningsbruggen S, Schoberth P, Szczepanski R, Dorsch W, Silbermann M, Wichmann HE, et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics. 1999; 58: 1-8.

Martinozzi S, Pacasova R, Boulouis HJ, Ulbrecht M, Weiss EH, Sigaux F, Pla M. Cutting edge: requirement of class I signal sequence-derived peptides for HLA-E recognition by a mouse cytotoxic T cell clone. J Immunol. 1999; 162: 5662-5.

Pacasova R, Martinozzi S, Boulouis HJ, Ulbrecht M, Vieville JC, Sigaux F, Weiss EH, Pla M. Cell-surface expression and alloantigenic function of a human nonclassical class I molecule (HLA-E) in transgenic mice. J Immunol. 1999; 62: 5190-6.

Borowski A, van Valen F, Ulbrecht M, Weiss EH, Blasczyk R, Jurgens H, Gobel U, Schneider EM. Monomorphic HLA class I-(non-A, non-B) expression on Ewing's tumor cell lines, modulation by TNF-alpha and IFN-gamma. Immunobiology. 1999; 200: 1-20.

Rebmann V, Pfeiffer K, Passler M, Ferrone S, Maier S, Weiss E, Grosse-Wilde H. Detection of soluble HLA-G molecules in plasma and amniotic fluid. Tissue Antigens. 1999; 53: 14-22.

Wierenga EA, Walchner M, Kick G, Kapsenberg ML, Weiss EH, Messer G. Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients. Int Immunol. 1999; 11: 297-306.

Ulbrecht M, Couturier A, Martinozzi S, Pla M, Srivastava R, Peterson PA, Weiss EH. Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences. Eur J Immunol. 1999; 29: 537-47.

Brooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, Weiss EH, Coligan JE. Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. J Immunol. 1999; 162: 305-13.

Rougier N, Kazatchkine MD, Rougier JP, Fremeaux-Bacchi V, Blouin J, Deschenes G, Soto B, Baudouin V, Pautard B, Proesmans W, Weiss E, Weiss L. Human complement factor H deficiency associated with hemolytic uremic syndrome. J Am Soc Nephrol. 1998; 9: 2318-26.

Weiss EH, Cannich A, Sprinks M, Fernandez N, Ulbrecht M. Unique biochemical properties of human leukocyte antigen-E allow for a highly specific function in immune recognition. Am J Reprod Immunol. 1998; 40: 177-82.

Ulbrecht M, Modrow S, Srivastava R, Peterson PA, Weiss EH. Interaction of HLA-E with peptides and the peptide transporter in vitro: implications for its function in antigen presentation. J Immunol. 1998; 160: 4375-85.

Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med. 1998; 187: 813-8.

de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH. Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing. Genomics. 1997; 45: 591-600.

Fiszer D, Ulbrecht M, Fernandez N, Johnson JP, Weiss EH, Kurpisz M. Analysis of HLA class Ib gene expression in male gametogenic cells. Eur J Immunol. 1997; 27: 1691-5.

Ulbrecht M, Eisenhut T, Bonisch J, Kruse R, Wjst M, Heinrich J, Wichmann HE, Weiss EH, Albert ED. High serum IgE concentrations: association with HLA-DR and markers on chromosome 5q31 and chromosome 11q13. J Allergy Clin Immunol. 1997; 99: 828-36.

Kuon W, Lauster R, Bottcher U, Koroknay A, Ulbrecht M, Hartmann M, Grolms M, Ugrinovic S, Braun J, Weiss EH, Sieper J. Recognition of chlamydial antigen by HLA-B27-restricted cytotoxic T cells in HLA-B*2705 transgenic CBA (H-2k) mice. Arthritis Rheum. 1997; 40: 945-54.

Frankenberger B, Breitkopf S, Albert E, Scholz S, Keller E, Schattenkirchner M, Weiss EH, Kellner H. Routine molecular genotyping of HLA-B27 in spondyloarthropathies overcomes the obstacles of serological typing and reveals an increased B *2702 frequency in ankylosing spondylitis. J Rheumatol. 1997; 24: 899-903.

Kirveskari J, Kellner H, Wuorela M, Soini H, Frankenberger B, Leirisalo-Repo M, Weiss EH, Granfors K. False-negative serological HLA-B27 typing results may be due to altered antigenic epitopes and can be detected by polymerase chain reaction. Br J Rheumatol. 1997; 36: 185-9.

Weissenhorn W, Chen YH, Reiter C, Federle C, Weiss EH, Riethmuller G, Rieber EP. Structural diversity of monoclonal CD4 antibodies and their capacity to block the HIV gp120/CD4 interaction. Hybridoma. 1996; 15: 117-24.

Zipp F, Weber F, Huber S, Sotgiu S, Czlonkowska A, Holler E, Albert E, Weiss EH, Wekerle H, Hohlfeld R. Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells. Ann Neurol. 1995; 38: 723-30.

Bensussan A, Mansur IG, Mallet V, Rodriguez AM, Girr M, Weiss EH, Brem G, Boumsell L, Gluckman E, Dausset J, et al. Detection of membrane-bound HLA-G translated products with a specific monoclonal antibody. Proc Natl Acad Sci U S A. 1995; 92: 10292-6.

Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y, Seldin MF, Ozato K, Inoko H, Taketo M. Physical mapping of the retinoid X receptor B gene in mouse and human. Immunogenetics. 1995; 41: 83-90.

de Baey A, Holzinger I, Scholz S, Keller E, Weiss EH, Albert E. Pvu II polymorphism in the primate homologue of the mouse B144 (LST-1). A novel marker gene within the tumor necrosis factor region. Hum Immunol. 1995; 42: 9-14.

Holzinger I, de Baey A, Messer G, Kick G, Zwierzina H, Weiss EH. Cloning and genomic characterization of LST1: a new gene in the human TNF region. Immunogenetics. 1995; 42: 315-22.

Krauss S, Kufer P, Federle C, Tabaszewski P, Weiss E, Rieber EP, Riethmuller G. Recombinant CD4-IgE, a novel hybrid molecule, inducing basophils to respond to human immunodeficiency virus (HIV) and HIV-infected target cells. Eur J Immunol. 1995; 25: 192-9.

Braun A, Kammerer S, Weissenhorn W, Weiss EH, Cleve H. Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1. Gene. 1994; 146: 291-5.

Guse AH, Milton AD, Schulze-Koops H, Muller B, Roth E, Simmer B, Wachter H, Weiss E, Emmrich F. Purification and analytical characterization of an anti-CD4 monoclonal antibody for human therapy. J Chromatogr A. 1994; 661: 13-23.

Volz A, Weiss E, Trowsdale J, Ziegler A. Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction. Hum Genet. 1994; 93: 42-6.

Ulbrecht M, Rehberger B, Strobel I, Messer G, Kind P, Degitz K, Bieber T, Weiss EH. HLA-G: expression in human keratinocytes in vitro and in human skin in vivo. Eur J Immunol. 1994; 24:176-80.

Schwaeble W, Luttig B, Sokolowski T, Estaller C, Weiss EH, Meyer zum Buschenfelde KH, Whaley K, Dippold W. Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase. Immunobiology. 1993; 188: 221-32.

Brockmeyer C, Ulbrecht M, Schendel DJ, Weiss EH, Hillebrand G, Burkhardt K, Land W, Gokel MJ, Riethmuller G, Feucht HE. Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection. Transplantation. 1993; 55: 610-5.

Bettinotti MP, Hartung K, Deicher H, Messer G, Keller E, Weiss EH, Albert ED. Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes. Immunogenetics. 1993; 37: 449-54.

Weissenhorn W, Scheuer W, Kaluza B, Schwirzke M, Reiter C, Flieger D, Lenz H, Weiss EH, Rieber EP, Riethmuller G, et al. Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the alpha-chain of the human interleukin-2 receptor. Gene. 1992; 121: 271-8.

Ulbrecht M, Honka T, Person S, Johnson JP, Weiss EH. The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein. J Immunol. 1992; 149: 2945-53.

Ulbrecht M, Kellermann J, Johnson JP, Weiss EH. Impaired intracellular transport and cell surface expression of nonpolymorphic HLA-E: evidence for inefficient peptide binding. J Exp Med. 1992; 176: 1083-90.

Steinkasserer A, Estaller C, Weiss EH, Sim RB. Human interleukin-1 receptor antagonist is expressed in liver. FEBS Lett. 1992; 310: 60-2.

Weissenhorn W, Chen YH, Riethmuller G, Rieber EP, Weiss EH. VH-related idiotopes detected by site-directed mutagenesis. A study induced by the failure to find CD4 anti-idiotypic antibodies mimicking the cellular receptor of HIV. J Immunol. 1992; 149: 1237-41.

Messer G, Zemmour J, Orr HT, Parham P, Weiss EH, Girdlestone J. HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A. Implications for the evolution of the HLA-A-related genes. J Immunol. 1992; 148: 4043-53.

Spengler U, Moller A, Jung MC, Messer G, Zachoval R, Hoffmann RM, Eisenburg J, Paumgartner G, Riethmuller G, Weiss EH, et al. T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation. J Hepatol. 1992; 15: 129-35.

Verjans GM, Messer G, Weiss EH, van der Linden SM, Kijlstra A. Polymorphism of the tumor necrosis factor region in relation to disease: an overview. Rheum Dis Clin North Am. 1992; 18: 177-86.

Zwirner J, Weissenhorn W, Karlsson L, Becker A, Rieber EP, Riethmuller G, Weiss EH, Peterson PA, Widera G. Expression of a functional chimeric Ig-MHC class II protein. J Immunol. 1992; 148: 272-6.

Messer G, Spengler U, Jung MC, Honold G, Eisenburg J, Scholz S, Albert ED, Pape GR, Riethmuller G, Weiss EH. Allelic variation in the TNF-beta gene does not explain the low TNF-beta response in patients with primary biliary cirrhosis. Scand J Immunol. 1991; 34: 735-40.

Weissenhorn W, Weiss E, Schwirzke M, Kaluza B, Weidle UH. Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction. Gene. 1991; 106: 273-7.

Steinkasserer A, Estaller C, Weiss EH, Sim RB, Day AJ. Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I. Biochem J. 1991; 277: 387-91.

Schwaeble W, Feifel E, Estaller C, Barbieri A, Molgg M, Koistinen V, Weiss EH, Dierich MP. Human complement factor H: molecular cloning and cDNA expression reveals variability in the factor H-related mRNA species of 1.4 kb. Immunobiology. 1991; 182: 307-22.

Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH. Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule. J Immunol. 1991; 146: 3190-6.

Estaller C, Schwaeble W, Dierich M, Weiss EH. Human complement factor H: two factor H proteins are derived from alternatively spliced transcripts. Eur J Immunol. 1991; 21: 799-802.

Schwemmle S, Bevec D, Brem G, Urban MB, Baeuerle PA, Weiss EH. Developmental and tissue-specific expression of the Q5k gene. Immunogenetics. 1991; 34: 28-38.

Messer G, Spengler U, Jung MC, Honold G, Blomer K, Pape GR, Riethmuller G, Weiss EH. Polymorphic structure of the tumor necrosis factor (TNF) locus: an Nco I polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 1991; 173: 209-19.

Messer G, Weiss EH, Baeuerle PA. Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter. Cytokine. 1990; 2: 389-97.

Mayer B, Funke I, Seed B, Riethmuller G, Weiss E. Expression of the CD6 T lymphocyte differentiation antigen in normal human brain. J Neuroimmunol. 1990; 29: 193-202.

Steinkasserer A, Weiss EH, Schwaeble W, Linke RP. Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis. Biochem J. 1990; 268: 187-93.

Weiss EH, Schliesser G, Botteron C, McMichael A, Riethmuller G, Kievits F, Ivanyi P, Brem G. HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man. Scand J Rheumatol Suppl. 1990; 87: 91-6.


Weiss EH, Ziegler A. HLA: genes and function. Immunol Today. 1989; 10: 16-8.

Weiss EH, Bevec D, Messer G, Schwemmle S, Grosshaus C, Steinmetz M, Schmidt W. Organization of the AKR Qa region: structure of a divergent class I sequence, Q5k. J Immunogenet. 1989; 16: 283-90.

Haas JG, Thiel C, Blomer K, Weiss EH, Riethmuller G, Ziegler-Heitbrock HW. Downregulation of tumor necrosis factor expression in the human Mono-Mac-6 cell line by lipopolysaccharide. J Leukoc Biol. 1989; 46: 11-4.

Thurau SR, Wildner G, Kuon W, Weiss EH, Riethmuller G. Expression and immunogenicity of HLA-B27 in high-transfection recipient P815: a new method to induce monoclonal antibodies directed against HLA-B27. Tissue Antigens. 1989; 33: 511-9.

Ragoussis J, Bloemer K, Pohla H, Messer G, Weiss EH, Ziegler A. A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line. Genomics. 1989; 4: 301-8.

Muller CA, Engler-Blum G, Gekeler V, Steiert I, Weiss E, Schmidt H. Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6. Immunogenetics. 1989; 30: 200-7.

Pohla H, Kuon W, Tabaczewski P, Doerner C, Weiss EH. Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles. Immunogenetics. 1989; 29: 297-307.

Feucht HE, Zwirner J, Bevec D, Lang M, Felber E, Riethmuller G, Weiss EH. Biosynthesis of complement C4 messenger RNA in normal human kidney. Nephron. 1989; 53: 338-42.

Wildner G, Weiss EH, Szots H, Riethmuller G, Schendel DJ. The use of fusion proteins to study HLA-B27-specific allorecognition. Mol Immunol. 1989; 26: 33-40.

Viitanen AM, Lahesmaa-Rantala R, Weiss E, Toivanen A. Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA. J Rheumatol. 1988; 15: 1123-5.

Robinson PJ, Bevec D, Mellor AL, Weiss EH. Sequence of the mouse Q4 class I gene and characterization of the gene product. Immunogenetics. 1988; 27: 79-86.

Ragoussis J, Bloemer K, Weiss EH, Ziegler A. Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis. Immunogenetics. 1988; 27: 66-9.

Weiss EH, Bloemer K, Doerner C, Kuon W, Lang M, Pohla H, Schattenkirchner M, Riethmuller G. Molecular biology of the HLA-B27 locus. Br J Rheumatol. 1988; 27 Suppl 2:12-8. Review.

Schwaeble W, Zwirner J, Schulz TF, Linke RP, Dierich MP, Weiss EH. Human complement factor H: expression of an additional truncated gene product of 43 kDa in human liver. Eur J Immunol. 1987; 17: 1485-9.

Funke I, Hahn A, Rieber EP, Weiss E, Riethmuller G. The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain. J Exp Med. 1987; 165: 1230-5.

Weiss EH. Molecular biology of the mouse Q region. Immunol Res. 1987; 6: 179-91. Review.

Schulz TF, Schwable W, Stanley KK, Weiss E, Dierich MP. Human complement factor H: isolation of cDNA clones and partial cDNA sequence of the 38-kDa tryptic fragment containing the binding site for C3b. Eur J Immunol. 1986; 16: 1351-5.

Meruelo D, Kornreich R, Rossomando A, Pampeno C, Boral A, Silver JL, Buxbaum J, Weiss EH, Devlin JJ, Mellor AL, et al. Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA. Proc Natl Acad Sci U S A. 1986; 83: 4504-8.

Szots H, Riethmuller G, Weiss E, Meo T. Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Proc Natl Acad Sci U S A. 1986; 83: 1428-32.

Geliebter J, Zeff RA, Schulze DH, Pease LR, Weiss EH, Mellor AL, Flavell RA, Nathenson SG. Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation. Mol Cell Biol. 1986; 6: 645-52.

Weiss EH, Kuon W, Dorner C, Lang M, Riethmuller G. Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations. Immunobiology. 1985; 170: 367-80.

Devlin JJ, Weiss EH, Paulson M, Flavell RA. Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. EMBO J. 1985; 4: 3203-7.

Schmidt W, Ferluga J, Festenstein H, Weiss E. Identification of murine H-2Db histocompatibility antigens in cells transfected with cloned H-2 genes. Mol Immunol. 1985; 22: 1151-8.

Devlin JJ, Widera G, Mellor AL, Fahrner K, Sherman D, Weiss EH, Flavell RA. Evolution and expression of the transplantation antigen gene family. Fed Proc. 1985; 44: 2736-40.

Weiss EH, Golden L, Fahrner K, Mellor AL, Devlin JJ, Bullman H, Tiddens H, Bud H, Flavell RA. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature. 1984; 310:650-5.

Meruelo D, Kornreich R, Rossomando A, Pampeno C, Mellor AL, Weiss EH, Flavell RA, Pellicer A. Murine leukemia virus sequences are encoded in the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1984; 81: 1804-8.

Mellor AL, Weiss EH, Kress M, Jay G, Flavell RA. A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell. 1984; 36: 139-44.

Mellor AL, Weiss EH, Ramachandran K, Flavell RA. A potential donor gene for the bm1 gene conversion event in the C57BL mouse. Nature. 1983; 306: 792-5.

Mellor AL, Golden L, Weiss E, Bullman H, Bud H, Flavell RA. Molecular cloning and analysis of H-2 class I genes of H-2b haplotype mice. Transplant Proc. 1983; 15: 2013-5.

Weiss EH, Mellor A, Golden L, Fahrner K, Simpson E, Hurst J, Flavell RA. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature. 1983; 301: 671-4.

Weiss EH, Mellor AL, Golden L, Bud H, Hurst J, Flavell RA, Simpson E, James R, Townsend AR, Festenstein H. Structure and expression of class I genes of the mouse major histocompatibility complex. Haematol Blood Transfus. 1983; 28: 454-8.

Weiss E, Golden L, Zakut R, Mellor A, Fahrner K, Kvist S, Flavell RA. The DNA sequence of the H-2Kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens. EMBO J. 1983; 2: 453-62.

Flavell RA, Grosveld F, Busslinger M, de Boer E, Kioussis D, Mellor AL, Golden L, Weiss E, Hurst J, Bud H, Bullman H, Simpson E, James R, Townsend AR, Taylor PM, Schmidt W, Ferluga J, Leben L, Santamaria M, Atfield G, Festenstein H. Structure and expression of the human globin genes and murine histocompatibility antigen genes. Cold Spring Harb Symp Quant Biol. 1983; 47: 1067-78.

Mellor AL, Golden L, Weiss E, Bullman H, Hurst J, Simpson E, James RF, Townsend AR, Taylor PM, Schmidt W, Ferluga J, Leben L, Santamaria M, Atfield G, Festenstein H, Flavell RA. Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. Nature. 1982; 298: 529-34.

Weiss EH, Cheah KS, Grosveld FG, Dahl HH, Solomon E, Flavell RA. Isolation and characterization of a human collagen alpha 1(I)-like gene from a cosmid library. Nucleic Acids Res. 1982; 10: 1981-94.

Flavell RA, Bud H, Bullman H, Busslinger M, deBoer E, deKleine A, Golden L, Groffen J, Grosveld FG, Mellor AL, Moschonas N, Weiss E. The structure and expression of mammalian gene clusters. Prog Clin Biol Res. 1982; 103: 37-55. 

Weiss E, Braun V. Actin-like protein of the cytoplasm in the chromatin of Dictyostelium discoideum. FEBS Lett. 1979 Dec 1;108(1):233-6.