Anthropology and Human Genetics
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Comparative and Population Genomics

We use genomic comparisons within and between species to understand the selective and neutral forces that shape genomes.

Methodologies

  • High-throughput sequencing analysis
  • Population genetics
  • Multivariate statistics

Relevant publications

Prufer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P.H., de Filippo, C., Li, H., Mallick, S., Dannemann, M., Fu, Q., Kircher, M., Kuhlwilm, M., Lachmann, M., Meyer, M., Ongyerth, M., Siebauer, M., Theunert, C., Tandon, A., Moorjani, P., Pickrell, J., Mullikin, J.C., Vohr, S.H., Green, R.E., Hellmann, I., Johnson, P.L., Blanche, H., Cann, H., Kitzman, J.O., Shendure, J., Eichler, E.E., Lein, E.S., Bakken, T.E., Golovanova, L.V., Doronichev, V.B., Shunkov, M.V., Derevianko, A.P., Viola, B., Slatkin, M., Reich, D., Kelso, J., and Paabo, S. (2014). The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 505, 43-49. http://www.ncbi.nlm.nih.gov/pubmed/24352235

Huber, C.D., Nordborg, M., Hermisson, J., and Hellmann, I. (2014). Keeping it Local: Evidence for Positive Selection in Swedish Arabidopsis thaliana. Molecular biology and evolution. http://www.ncbi.nlm.nih.gov/pubmed/25158800

Prufer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J.R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J.R., Mullikin, J.C., Meader, S.J., Ponting, C.P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoc, E., Alkan, C., Sajjadian, S., Catacchio, C.R., Ventura, M., Marques-Bonet, T., Eichler, E.E., Andre, C., Atencia, R., Mugisha, L., Junhold, J., Patterson, N, Siebauer, M., Good, J.M., Fischer, A., Ptak, S.E., Lachmann, M., Symer, D.E., Mailund, T., Schierup, M.H., Andres, A.M., Kelso, J., and Paabo, S. (2012). The bonobo genome compared with the chimpanzee and human genomes. Nature 486, 527-531, http://www.ncbi.nlm.nih.gov/pubmed/22722832.

Johnson, P.L., and Hellmann, I. (2011). Mutation rate distribution inferred from coincident SNPs and coincident substitutions. Genome Biol Evol 3, 842-850, http://www.ncbi.nlm.nih.gov/pubmed/21572094.

Pool, J.E., Hellmann, I., Jensen, J.D., and Nielsen, R. (2010). Population genetic inference from genomic sequence variation. Genome Res 20, 291-300, http://www.ncbi.nlm.nih.gov/pubmed/20067940.

Hellmann, I., Mang, Y., Gu, Z., Li, P., de la Vega, F.M., Clark, A.G., and Nielsen, R. (2008). Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res 18, 1020-1029, http://www.ncbi.nlm.nih.gov/pubmed/18411405.