Anthropology and Human Genetics

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Nuclear Architecture


Hübner B, Lomiento M, Mammoli F, Illner D, Markaki Y, Ferrari S, Cremer M, Cremer T (2015) Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactiv nuclear compartments. Epigenetics & Chromatin 8:47

Cremer T, Cremer M, Hübner B, Strickfaden H, Smeets D, Popken J, Sterr M, Markaki J, Rippe K, Cremer C (2015) The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments. FEBS Letters 589: 2931-2943

Popken J, Graf A, Krebs S, Blum H, Schmid VJ, Strauss A, Guengoer T, Zakhartchenko V, Wolf E, Cremer T (2015) Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. PLoS ONE 05/2015; 10(5):e0124619.


Popken J, Brero , Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T (2014). Functional reprogramming of fibroblast nuclei in cloned bovine embryos is paralleled by major structural remodeling with both striking similarities and differences to nuclear phenotypes of embryos fertilized in vitro. Nucleus 5(6): 555-589

Popken J, Koehler D, Brero A, Wuensch A, Guengoer T, Thormeyer T, Wolf E, Cremer T, Zakhartchenko V (2014). Positional changes of a pluripotency marker gene during structural reorganization of fibroblast nuclei in cloned early bovine embryos. Nucleus 5(6): 542-554

Smeets D, Markaki Y, Schmid VJ, Kraus F, Tattermusch A, Cerase A, Sterr M, Fiedler S, Demmerle J, Popken J, Leonhardt H, Brockdorff N, Cremer T, Schermelleh L, Cremer M (2014) Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics & Chromatin 7:8

Cremer T, Cremer C, Lichter P (2014) Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization. Hum Genet 133: 403-16


Cremer T (2013) Nuclear architecture and function studied in space and time: origin, current state and perspectives (Schleiden lecture at the DGZ meeting March 2013). Cell News 39: 6-13

Hübner B, Cremer T, Neumann J (2013) Correlative microscopy of individual cells – sequential application of microscopic systems with increasing resolution to study the nuclear landscape. Methods Mol Biol 1042: 299-336

Markaki Y, Smeets D, Cremer M, Schermelleh L (2013) Fluorescence in situ hybridization applications for super-resolution 3D structured illumination microscopy. Methods Mol Biol 950: 43-64

Walczak A, Szczepankiewicz A, Ruszczycki B, Zamłyńska K, Dzwonek J, Wilczek E, Żybura-Broda K, Rylski M, Szczepińska T, Pawłowski K, Włodarczyk J, Szczerbal5, Marek Świtoński I, Cremer M, Wilczyński G (2013) Novel higher-order epigenetic regulation of bdnf gene upon seizures. J Neuroscience 33: 2507-11


Popken J, Sterr M, Markaki Y, Cremer M, Beck A, Dahlhoff M, Habermann FA, Fezert P, Guengoer T, Reichenbach M, Wuensch A, Wolf E, Zakhartchenko V, Cremer T (2012) Studies of nuclear architecture in mammalian pre-implantation embryos and embryonic stem cells using super-resolution fluorescence microscopy. Reprod Fertil Dev 25:200

Markaki Y, Smeets D, Fiedler S, Schmid VJ, Schermelleh L, Cremer T, Cremer M (2012) The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture. BioEssays 34: 412-26

Cremer M, Markaki Y, Zunhammer A, Cremer C, Cremer T (2012) Chromatin in the Cell Nucleus: Higher-order Organization. Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0005768.pub2

Cremer T, Markaki Y, Hübner B, Zunhammer A, Strickfaden H, Beichmanis S, Heß M, Schermelleh L, Cremer M and Cremer C (2012) Chromosome territory organisation within the nucleus (2012) Advances in Molecular Biology and Medicine (Vol. 1). Epigenetic Regulation and Epigenomics Edited by Robert A. Meyers.Wiley-VCH. Vol 1: 451-483

Neumann LC, Markaki Y, Mladenov E, Hoffmann D, Buiting K, Horsthemke B (2012) The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein. Hum Mol Genet 18: 4038-48

Prudovsky I, Vary, CP, Markaki Y, Olins, AL, Olins, DE (2012) Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes. Nucleus 2: 200-210

Kölbl AC, Weigl D, Mulaw M, Thormeyer T, Bohlander SK, Cremer T, Dietzel S (2012) The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains. Chromosome Res 20: 735-52


Teller K, Illner D, Thamm S, Casas-Delucchi CS, Versteeg R, Indemans M, Cremer T, Cremer M (2011) A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at ≥20 Mb genomic length scales. Nucleus 2: 465-477

Cremer T und Cremer M (2011) Über ethische Verantwortbarkeit und Gewissensfreiräume (1) Freigabe der Präimplantationsdiagnostik: Ergebnisoffene, genetische Beratung und weltanschauliche Dimension der PID-Debatte. Gyne 32: 28-32(in German)

Cremer T & Cremer M (2011) Freigabe der Präimplantationsdiagnostik: Über ethische Verantwortbarkeit und Gewissensfreiräume Gyne 32: 20 – 23(in German)

Jost KL, Haase S, Smeets D, Schrode N, Schmiedel JM, Bertulat B, Herzel H, Cremer M, Cardoso MC (2011) 3D-image analysis platform monitoring relocation of pluripotency genes during reprogramming. Nucleic Acids Res 39 (17): e113

Strickfaden H, Cremer T, Rippe K, (2011) Higher order chromatin organization and dynamics. In: Genome organization and function in the cell nucleus (K. Rippe ed.), Wiley-VCH

Cremer, T., Zakhartchenko, V. (2011) Nuclear architecture in developmental biology and cell specialisation. Reprod Fert Develop 23: 1-12

Niedojadlo J, Perret-Vivancos C, Kalland K-H, Cmarko D, Cremer T, van Driel R, Fakan S (2011) Transcribed DNA is preferentially located in the perichromatin region of mammalian cell nuclei. Exp Cell Res 317: 433-444

Casas-Delucchi CS, Brero, A, Rahn HP, Solovei I, Wutz A, Cremer T, Leonhardt H, Cardoso MC (2011) Histone acetylation controls the inactive X chromosome replication dynamics. Nat Commun 2: article number 222


Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M (2010) Remodeling of nuclear rchitecture by the thiodioxopiperazine metabolite chaetocin. Exp Cell Res 316: 1662-80

Solovei I and Cremer M (2010) 3D-FISH on Cultured Cells Combined with Immunostaining. Methods Mol Biol 659: 117-26

Cremer T (2010) Von der Genetik zur Epigenetik und Epigenomforschung – Essay zur Geschichte der Vererbungsforschung und zur Zukunft der prädiktiven Medizin. Leopoldina NF 98, Nr. 361, 87–165

Cremer T and Cremer M (2010) Chromosome territories. Cold Spring Harb. Perspectives in Biology, 2, a003889

Meggendorfer M, Weierich C, Wolff H, Brack-Werner R, Cremer T (2010) Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters. Chromosome Res. 18: 401-417

Németh A, Cones A, Santoyo-Lopez J, Medina I, Montaner D, Péterfia B, Solovei I, Cremer T, Dopazo J, Längst G (2010) Initial Genomics of the Human Nucleolus. PLoS Genet 6(3): e1000889

Postberg J, Lipps, HJ, Cremer T (2010) Evolutionary origin of the cell nucleus and its functional architecture. Essays in Biochemistry: Epigenetics, Disease and Behaviour 48: 1–24

Rouquette J, Cremer C, Cremer T, Fakan S (2010) Functional nuclear architecture studied by microscopy: Present and future. Int Rev Cell Mol Bio 282: 1-156

Strickfaden H, Zunhammer A, van Koningsbruggen S, Koehler D, Cremer T (2010) 4D chromatin dynamics in cycling cells: Theodor Boveri’s hypotheses revisited. Nucleus 1: 284-297

Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M., Leonhardt H, Eick D, Cremer C, Cremer T (2010) Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment. Cold Spring Harb Sym Quant. Biol., Nuclear Organization and Function 75: 475-492

Koehler D, Zakhartchenko V, Ketterl N, Wolf E, Cremer T, Brero A (2010) FISH on 3D Preserved Bovine and Murine Preimplantation Embryos. Meth Mol Biol 659: 437-45



Solovei I, Kreysing M, Lanctot C, Koesem S, Peichl L, Cremer T, Guck J, Joffe B (2009) Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution. Cell 137: 356-368

Hable V, Greubel C, Bergmaier A, Reichart P, Hauptner A, Krücken R, Strickfaden H, Dietzel S, Cremer T, Drexler GA, Friedl AA, Dollinger G (2009).The Live Cell Irradiation- and Observation Setup at SNAKE. Nuclear Instruments and Methods in Physics Research B 267: 2090-2097

Koehler D, Zakhartchenko V, Froenicke L, Stone G, Stanyon R, Wolf E, Cremer T, Brero A (2009). Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos. Exp Cell Res 315: 2053-2063

Koehler D, Zakhartchenko V, Ketterl N, Wolf E, Cremer T, Brero A (2009) FISH on 3D preserved preimplantation embryos. In: Methods in Molecular Biology Series (eds J. M. Bridger and E. Volpi). Humana Press

Brero A, Hao R, Schieker M, Wierer M, Wolf E, Cremer T, Zakhartchenko V (2009) Differential reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts. Cloning and Stem Cells 11: 319-329

Hübner B, Strickfaden H, Müller S, Cremer M, Cremer T (2009) Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. European Biophysics J 38: 729-747

Rouquette J, Genoud C, Vazquez-Nin GH, Kraus B, Cremer T, Fakan S (2009) Revealing the high-resolution three-dimensional network of chromatin and interchromatin space: A novel electron-microscopic approach to reconstructing nuclear architecture. Chromosome Res. 17: 801-810

Müller S, Cremer M, Neusser, Grasser F, Cremer T (2009) Quantum dots in multi-colour fluorescence in situ hybridisation: a technical note. Cytogenetics and Genome Research 124: 351-359



Grasser F, Neusser M, Fiegler H, Thormeyer T, Cremer M, Carter N, Cremer T, Müller S (2008) Replication timing correlated spatial chromatin arrangements in cancer and primate interphase nuclei. J Cell Sci 121: 1876-188

Ronneberger O, Baddeley D, Scheipl F, Verveer PJ, Burkhardt H, Cremer C, Fahrmeir L, Cremer T, Joffe B (2008) Spatial quantitative analysis of fluorescently labeled nuclear structures: Problems, methods, pitfalls. Chromosome Res 16: 523-62

Yang S, Koehler D, Teller K, Cremer T, Le Baccon P, Heard E, Eils R, Rohr K (2008) Nonrigid registration of 3-d multichannel microscopy images of cell nuclei IEEE Trans Image Process 17: 493-9

Yang S, Illner D, Teller K, Solovei I, van Driel R, Joffe B, Cremer T, Eils R, Rohr K (2008) Structural Analysis of Interphase X Chromatin Fiber Based on Statistical Shape Theory. Biochim Biophys Acta Molecular Cell Research, 1783:2089-2099

Greubel C, Hable V, Drexler GA, Hauptner A, Dietzel S, Strickfaden H, Baur I, Krücken R, Cremer T, Dollinger, Friedl AA (2008) Competition effect in DNA damage response. Radiat Environ Biophys 47:423-429

Greubel C, Hable V, Drexler GA, Hauptner A, Dietzel S, Strickfaden H, Baur I, Krücken R, Cremer T, Friedl AA, Dollinger G. (2008) Quantitative analysis of DNA-damage response factors after sequential ion micro-irradiation. Radiat Environ Biophys. 47: 415-422

Postberg J, Heyse K, Cremer M, Cremer T, Lipps HJ (2008) Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development. Epigenetics & Chromatin 1:3

Shimi T, Pfleghaar K, Kojima SI, Pack CG, Solovei I, Goldman AE, Adam SA, Shumaker DK, Kinjo M, Cremer T, Goldman RD (2008) The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes & Development 22: 3409-3421

Cremer M, Grasser F, Lanctot C, Müller S, Neußer M, Solovei I, Zinner R, Cremer T (2008) Multicolor 3D-FISH for imaging interphase chromosomes. Methods Mol Biol 463: 205-39

Cremer M, Müller S, Solovei I, Cremer T (2008) 3D FISH und Zellkernarchitektur. Medizinische Genetik 20 (4): 379-385 (in German)



Lanctôt C, Cheutin T, Cremer M, Cavalli G, Cremer T (2007) Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nature Rev Genet 8: 105-115

Lanctôt C, Kaspar C, Cremer T (2007) Positioning of the mouse Hox clusters in the nuclei of developing embryos and differentiating embryoid bodies. Exp Cell Res 313: 1449-1459

Merico V, Barbieri J, Zuccotti M, Joffe B, Cremer T, Redi CA, Solovei I, Garagna S (2007) Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos. Chromosome Res 15: 341-360

Zinner R, Teller K, Versteeg R, Cremer T, Cremer M (2007) Biochemistry meets nuclear architecture: Multicolor immuno-FISH for colocalization analysis of chromosome segments and differentially expressed gene loci with various histone methylations. Advan Enzyme Regul 47: 223-241

Teller K, Solovei I, Buiting K, Horsthemke B, Cremer T (2007) Maintenance of imprinting and nuclear architecture in cycling cells. Proc Natl Acad Sci USA 104: 14970-14975 Stehle IM, Postberg J, Rupprecht S, Cremer T, Jackson DA, Lipps HJ (2007) Establishment and mitotic stability of an extra-chromosomal mammalian replicon. BMC Cell Biology 8: 33

Klier AB, Cremer T (2007) Entwicklung zum Tod: der Prozess des Alterns aus evolutionsbiologischer Sicht. In: Naturwissenschaftlich fundierte Ökologie. Wissen, Verantwortung, Aufgaben. 2007. Herausgegeben von Gerhard Wegner. Reihe Grenzfragen. Band 30. Albers Verlag, Freiburg i. Br. ISBN 978-3-495-48145-5 (in German)

Mateos-Langerak J, Goetze S, Leonhardt H, Cremer T, van Driel R, Lanctôt C (2007) Nuclear architecture: is it important for genome function and can we prove it? J Cell Biochem 102: 1067-1075

Rauch J, Knoch TA, Solovei I, Teller K, Stein S, Buiting K, Horsthemke B, Langowski J, Cremer T, Hausmann M, Cremer C (2007) Light optical precision measurements of the active and inactive Prader–Willi syndrome imprinted regions in human cell nuclei. Differentiation 76: 66-82

Tashiro S, Cremer M, Solovei I, Cremer T (2007) Nuclear architecture: Topology and function of chromatin- and non-chromatin nuclear domains. In: Nuclear Dynamics, Molecular Biology and Visualization of the nucleus. Springer, eds. K. Nagata and K. Takeyasu

Müller S, Neusser M, Köhler D, Cremer M. (2007) Preparation of complex DNA probe sets for 3D FISH with up to six different fluorochromes CSH Protocols; doi:10.1101/pdb.prot4730

Cremer M, Müller S, Köhler D, Brero A, Solovei I (2007) Cell preparation and multicolor FISH in 3D preserved cultured mammalian cells. CSH protocols. doi:10.1101/pdb.prot4723 2006


Zinner R, Albiez H, Walter J, Peters AHF, Cremer T, Cremer M (2006) Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones. Histochem Cell Biol 125: 3-19

Dollinger G, Bergmaier A, Hauptner A, Dietzel S, Drexler GA, Greubel C, Hable V, Reichart P, Krücken R, Cremer T, Friedl AA. (2006) Hydrogen microscopy and analysis of DNA repair using focused high energy ion beams. Nuclear Instruments and Methods in Physics Research B 249: 270-277

A. Hauptner A, Krücken R, Greubel C, Hable V, Dollinger G, Drexler GA, Deutsch M, Löwe R, Friedl AA, Dietzel S, Strickfaden, Cremer T (2006) DNA-repair protein distribution along the tracks of energetic ions. Radiation Prot Dosimetry 122: 147-149

Hable V, Dollinger G, Greubel C, Hauptner a, Krücken R, Dietzel S, Cremer T, Drexler GA, Friedl AA, Löwe R (2006) Methods for quantitative evaluation of dynamics of repair proteins within irradiated cells. Nuclear Instruments and Methods in Physics Research B 245 (2006) 298–301

Cremer T, Cremer M, Dietzel S, Müller S, Solovei 1, Fakan S (2006) Chromosome territories – a functional nuclear landscape. Curr Opin Cell Biol 18: 307–316

Walter J, Joffe B, Bolzer A, Albiez H, Benedetti PA, Müller S, Speicher MR, Cremer T, Cremer M, Solovei I (2006) Towards many colors in FISH on 3D-preserved interphase nuclei. Cytogenet Genome Res 114: 367-378

Albiez H, Cremer M, Tiberi C, Vecchio L, Schermelleh L, Dittrich S, Küpper K, Joffe B, Thormeyer T, von Hase J, Yang S, Rohr K, Leonhardt H, Solovei I, Cremer C, Fakan S, Cremer T (2006) Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. Chromosome Res 14: 707-733

Yang S, Köhler D, Teller D, Cremer T, Le Baccon P, Heard E, Eils R, Rohr K (2006) Non-rigid Registration of 3D Multi-channel Microscopy Images of Cell Nuclei. In: R. Larsen, M. Nielsen, and J. Sporring (Eds.): MICCAI 2006, LNCS 4190, pp. 907–914. Springer-Verlag Berlin Heidelberg 2006

Cremer T, Cremer C (2006). Rise, fall and resurrection of chromosome territories: a historical perspective. Part I. The rise of chromosome territories. Eur J Histochem 50: 161-176

Cremer T, Cremer C (2006) Rise, fall and resurrection of chromosome territories: a historical perspective Part II. Fall and resurrection of chromosome territories during the 1950s to 1980s. Part III. Chromosome territories and the functional nuclear architecture: experiments and models from the 1990s to the present. Eur J Histochem 50: 223-272

Cremer T, Klier-Choroba AB (2006) Jenseits von Eden: Zum Konflikt zwischen naturwissenschaftlicher und christlicher Anthropologie. In: Gärten, Parkanlagen und Kommunikation. Lebensräume zwischen Privatsphäre und Öffentlichkeit, Duttge G und Tinnefeld M-T (Hrsg.). Berlin: Berliner Wissenschafts Verlag (in German)

Hauptner A, Friedland W, Dietzel S, Drexler GA, Greubel C, Hable V, Strickfaden H, Cremer T, Friedl AA, Krücken R, Paretzke HG and Dollinger G (2006) Spatial Distribution of DNA Double-Strand Breaks from Ion Tracks. In: Ion Beam Science: Solved and Unsolved Problems. Edited by Peter Sigmund. Matematisk-fysiske Meddelelser 52, p. 59-85. ISSN 0023-3323 ISBN 87-7304-330-3. Free Download PDF

Cremer M, Weiereich C, Solovei I (2006) Multicolor 3D-FISH in vertebrate cells. edited by The Epigenome Network of Excellence

Fischer C, Gross W, Krüger J, Cremer M, Vogel F, Grimm T (2006) Modelling Germline Mosaicism and Different New Mutation Rates Simultaneously for Appropriate Risk Calculations in Families with Duchenne Muscular Dystrophy. Ann Hum Genet 70: 237-248


Bolzer, A., Kreth, G., Solovei, I., Koehler, D., Saracoglu S., Fauth, C., Müller, S., Eils, R., Cremer, C., Speicher, M.R., Cremer, T. Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes. PLoS Biol 3 (5): e157 (2005)

Brero A, Easwaran HP, Nowak D, Grunewald I, Cremer T, Leonhardt H, Cardoso MC (2005) Methyl CpG–binding proteins induce large-scale chromatin reorganization during terminal differentiation. J Cell Biol 169: 733-743

Dollinger G, Hable V, Hauptner A, Krücken R, Reichart P, Friedl AA, Drexler G, Cremer T, Diezel S. 2005. Microirradiation of cells with energetic heavy ions. Nuclear Instruments and Methods in Physics. Research Section B. Beam interactions with materials and atoms 231: 195-201

Lux C, Albiez H, Chapman RD, Heidinger M, Meininghaus M, Brack-Werner R, Lang A, Ziegler M, Cremer T, Eick D. 2005. Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II. Nucleic Acids Research 33: 5139-5144 IF: 6.31

Postberg J, Alexandrova O, Cremer T, Lipps HJ. 2005. Exploiting nuclear duality of ciliates to analyse topological requirements for DNA replication and transcription. J Cell Science 118: 3973-3983.

Mayer R, Brero A, von Hase J, Schroeder T, Cremer T, Dietzel S (2005) Common themes and cell type specific variations of higher order chromatin arrangements in the mouse. BMC Cell Biology 6:44



Hauptner A, Dietzel S, Drexler GA, Reichart P, Krücken R, CremerT, Friedl AA, Dollinger G (2004) Microirradiation of cells with energetic heavy ions. Radiat. Environ Biophys 42: 237–245

Cremer M, Zinner R, Stein S, Albiez H, Wagler B, Cremer C, Cremer T (2004) Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei. Eur J Histochem 48:15-28

Solovei I, Grandi N, Knoth R, Volk B, Cremer T (2004) Postnatal changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development. Cytogenet Genome Res 105: 302 - 310

Solovei I, Schermelleh L, Albiez H, Cremer T (2004) Detection of the cell cycle stages in situ in growing cell populations. In: Celis J, editor.Celis Js. Cell Biology Handbook: A Laboratory Manual, 3rd Edition. San Diego: Academic Press, NYP

Solovei I, Schermelleh L, Düring K, Engelhardt A, Stein S, von Hase J, Cremer C, Cremer T (2004) Differences in centromere positioning of cycling and postmitotic human cell types. Chromosoma 112: 410-423

Cremer T, Küpper K, Dietzel S, Fakan S (2004) Higher order chromatin architecture in the cell nucleus: On the way from structure to function. Biology of the Cell 96: 555-567

Cremer T, Cremer M, Solovei I, Dietzel S (2004) Variable Chromatinanordnung und ihre Bedeutung für die Genregulation. BIOspektrum 10: 373-377 (in German)

Stadler S, Schnapp V, Mayer R, Stein S, Cremer C, Bonifer C, Cremer T, Dietzel, S (2004) The architecture of chicken chromosome territories changes during differentiation. BMC Cell Biology 5:44

Kreth G, Finsterle J, v. Hase J, Cremer M, Cremer C (2004) Radial arrangement of chromosome territories in human cell nuclei: a computer model approach based on gene density indicates a probabilistic global positioning code. Biophys J 86: 2803-2812



Cremer T and Cremer C (2003) Chromatin in the Cell Nucleus: Higher-order Organization. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 1, pp. 514-518. London: Nature Publishing Group

Cremer M, Schermelleh L, Solovei I and Cremer T (2003) Cell Cycle: Chromosomal Organization. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 1, pp. 451-457. London: Nature Publishing Group

Walter J, Schermelleh L, Cremer M, Tashiro S, Cremer T. Chromosome order changes during mitosis and early G1, but is stably maintained during subsequent interphase stages, J. Cell Biol., 160: 685 – 697 (2003)

Walter J, Cremer T, Myagawa K, Tashiro S. 2003. A new system for laser-uv-microirradiation of  living cells. J. Microsc 209: 71 – 75. IF:1.9

Cremer M, Küpper  K, Wagler B, Wizelman L,  von Hase J, Weiland Y, Kreja L, Diebold J, Speicher MR, Cremer T (2003) Inheritance of gene density–related higher order chromatin arrangements in normal and tumor cell nuclei, J. Cell Biol., 162: 809 – 820 IF: 10.15

Weierich C, Brero A, Stein S, von Hase J, Cremer C, Cremer T, Solovei I (2003) Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. Chromosome Res 11: 485 – 502

Alexandrova O, Solovei I, Cremer T, David CN (2003) Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra. Chromosoma 112: 190-200

Cremer T, M. Cremer, B. Wagler, J. Walter, L. Schermelleh (2003) Imaging of human cell nuclei in space of time. Zellbiologie aktuell 3/2003: 21 – 24


Tanabe H, Müller S, Neusser M, von Hase J, Calcagno E, Cremer M, Solovei, I, Cremer C, Cremer T. Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc Natl Acad  Sciences USA, 99: 4424-4429 (2002)

Solovei I, Walter J, Cremer M, Habermann F, Schermelleh L, Cremer T. (2002) FISH on three-dimensionally preserved nuclei. In: FISH: a practical approach (B. Beatty , S. Mai and J. Squire, eds.), pp. 119-157. Oxford University press.

Tanabe H, Habermann F, Solovei I, Cremer M, Cremer T (2002) Non-random radial arrangements of interphase chromosome territories: Evolutionary considerations and functional implications. Mutation Research 504: 37-45

Solovei I, Cavallo A, Schermelleh L, Jaunin F, Scasselati C, Cmarko D, Cremer C, Fakan, S, Cremer T (2002) Spatial preservation of nuclear chromatin architecture during three-dimensional fluorescence in situ hybridization. Exp Cell Res 276: 10-23


Schermelleh L, Solovei I, Zink D, Cremer T (2001) Two-color fluorescence labeling of early and mid to late replicating chromatin in living cells. Chromosome Res 9: 77-80

Cremer, T. & Cremer, C. Chromosome Territories, Nuclear Architecture and Gene Regulation in Mammalian Cells. Nature Reviews Genetics 2, 292-301 (2001).

Cremer M, von Hase J, Volm T, Brero A, Kreth G, Walter J, Fischer C, Solovei I, Cremer C, Cremer T (2001) Non-random radial higher order chromatin arrangements in nuclei of diploid human cells. Chromosome Res 9: 541-547

Habermann FA, Cremer M, Walter J, Kreth G, von Hase J, Bauer K, Wienberg J, Cremer C, Cremer T, Solovei I (2001) Arrangements of macro- and microchromosomes in chicken cells. Chromosome Res 9, 569-584

Edelmann P, Bornfleth H, Zink D, Cremer T, Cremer C (2001) Morphology and dynamics of chromosome territories in living cells. Biochim Biophys Acta 1551: 29 – 40


Bornfleth H, Cremer C, Cremer T, Dietzel S, Edelmann P, Eils R, Jäger W, Kienle D, Kreth G, Lichter P, Little G, Münkel C, Langowski J, Solovei I. Stelzer EHK, Zink D. (2000) Analysis of chromosome territory architecture in the human cell nucleus: overview of data from a collaborative study. In: Genomics and Proteomics. Functional and Computational Aspects, S. Suhai ed., 133 – 140, Kluwer Academic/ Plenum Publishers, New York, Boston, Dordrecht, London, Moscow

Leonhardt H, Rahn HP, Weinzierl P, Sporbert A, Cremer T, Zink D, Cardoso MC (2000) Dynamics of DNA replication factories in living cells. J Cell Biol 149: 271-279

Cremer T, Kreth G, Koester H, Fink RHA, Heintzmann R, Cremer M, Solovei I, Zink D, Cremer C (2000) Chromosome Territories, Interchromatin Domain Compartment and Nuclear Matrix: an Integrated View of the Functional Nuclear Architecture. Crit Rev Eukar Gene 10: 179-212

Tashiro S, Walther J, Shinohara, A, Kamada N, Cremer T (2000) Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. J Cell Biol 150: 283-291

Solovei I, Kienle D, Little G, Eils R, Savelyeva L, Schwab M, Jäger W, Cremer C, Cremer T (2000) Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines. Genes, Chromosomes & Cancer 29: 297-308


P. Marko, E. Gerlach, H.G. Zimmer, I. Pechan, T. Cremer, C. Trendelenburg (1969): Interrelationship between salvage pathway and synthesis de novo of adenine nucleotides in kidney slices. Hoppe-Seyler's Z. Physiol. Chem. 350, 1669-1674

W. Dames, V. Neuhoff, T. Cremer (1972): Mikroelektrophoretische Trennung und Bestimmung von Dehydrogenasen einzelner Zellen. Naturwissenschaften 59, 126

T. Cremer, W. Dames, V. Neuhoff (1972): Micro disc electrophoresis and quantitative assay of glucose-6-phosphate dehydrogenase at the cellular level. Hoppe Seyler's Z. Physiol. Chem. 353, 1317-1329

C. Cremer, C. Zorn, T. Cremer (1974): An ultraviolet lasermicrobeam for 257 nm. Microscopia Acta 75, 331-337

C. Zorn, C. Cremer, T. Cremer (1974): A continuous wave ultraviolet laser microbeam and its use for studies in somatic cell genetics. In: Proc. '74 El.-Opt. Int. Conf., Kiver Comm. Ltd., Surrey, England, pp. 203-210

C. Cremer, T. Cremer, C. Zorn, L. Schoeller (1976): Effects of laser-uv- microirradiation on proliferation of Chinese hamster cells. Radiat. Res. 66, 106-121

T. Cremer, C. Zorn, C. Cremer, J. Zimmer (1976): Formation of viable cell fragments by treatment with colchicine. Exp. Cell Res. 100, 345-355

C. Zorn, T. Cremer, C. Cremer, J. Zimmer (1976): Laser-UV-microirradiation of interphase nuclei and posttreatment with caffeine: a new approach to establish the arrangement of interphase chromosomes. Hum. Genet. 35, 83-89

*C. Zorn, C. Cremer, T. Cremer, J. Zimmer (1977): Laser-uv-microirradiation (l = 257 nm) of Chinese hamster cells: evidence of uv-induced chromosome aberrations which do not originate at the sites of photolesions in the chromatin. In: Proceedings of the Symposium "Lasers in Medicine and Biology" Neuherberg (F. Hillenkamp and R. Kaufmann, eds), Gesellschaft für Strahlen- und Umweltforschung, Neuherberg, pp. 30/1-30/9

A.F.G. Stevenson, T. Cremer, O. Messerschmidt (1977): Erholung und zytogerontologische Aspekte der menschlichen Bindegewebszellen nach Röntgen- und Neutronenbestrahlung. In: Strahlenschutz in Forschung und Praxis, Band XVIII (O. Messerschmidt, G. Möhrle, R. Zimmer u.a., eds), Georg Thieme Verlag Stuttgart, 1977, pp. 20-29

C. Cremer, T. Cremer (1978): Considerations on a laser-scanning-microscope with high resolution and depth of field. Microscopica Acta 81, 31-44

C. Zorn, C. Cremer, T. Cremer, J. Zimmer (1979): Unscheduled DNA synthesis after partial uv irradiation of the cell nucleus. Distribution in interphase and metaphase. Exp. Cell Res. 124, 111-119

M. Lohs-Schardin, K. Sander, C. Cremer, T. Cremer, C. Zorn (1979): Localized ultraviolet laser microbeam irradiation of early Drosophila embryos: fate maps based on location and frequency of adult effects. Develop. Biol. 68, 533-545

T. Cremer (1980): August Weimann's contribution to cytogerontology. In: Conference on structural pathology in DNA and the biology of ageing. Zentrallaboratorium für Mutagenitätsprüfung der Deutschen Forschungsgemeinschaft, Jahreskonferenz 1979, Boldt Verlag, Boppard, pp. 283-306

T. Cremer, C. Cremer, J. Zimmer, C. Zorn (1980): UV-micro-irradiation of Chinese hamster cells and posttreatment with caffeine: Indication for clastogenic effects remote from the irradiation site. In: DNA-Repair and Late Effects (H. Altmann, E. Riklis, H. Slor, eds.), Publ. NRCN (Israel), S. 53-62.

C. Cremer, T. Cremer, M. Fukuda, K. Nakanishi (1980): Detection of laser-uv-microirradiation induced DNA photolesions by immuno-fluorescent staining. Hum. Genet. 54, 107-110

C. Cremer, T. Cremer, M. Simickova (1980): Induction of chromosome shattering and micronuclei by ultraviolet light and caffeine. I. Temporal relationship and antagonistic effects of the four deoxyribonucleosides. Environm. Mutagen. 2, 339-351

K. Werdan, K. Lehner, T. Cremer, A.F.G. Stevenson, O. Messerschmidt (1980): D-glucose uptake into suspended human fibroblasts. Rapid measurement of uptake by silicone oil filtration centrifugation and comparison of different cell detachment procedures. Hoppe Seyler's Z. Physiol. Chem. 361, 91-104

T. Cremer, S.P. Peterson, C. Cremer, M.W. Berns (1981): Micro-irradiation of Chinese hamster cells at wavelength 365 nm. Effects of psoralen and caffeine. Radiat. Res. 85, 529-543

T. Cremer, A. Turner, L.H. Liaw, M.W. Berns (1981): Giant cell formation produced by laser microbeam irradiation (l = 532 nm) of chromatin in Chinese hamster cells. Exp. Cell Res. 134, 49-63

A.F.G. Stevenson, T. Cremer (1981): Senescence in vitro and ionising radiations - the HDF model. Mech. Age. Dev. 15, 51-63

C. Cremer, T. Cremer, G. Jabbur (1981): Laser-uv-microirradiation of Chinese hamster cells. The influence of the distribution of photolesions on unscheduled DNA synthesis. Photochem. Photobiol. 33, 925-928

C. Cremer, T. Cremer, C. Zorn, J. Zimmer (1981): Induction of chromosome shattering by ultraviolet light and caffeine. Comparison of whole cell and partial cell irradiation. Mutat. Res. 84, 331-348

T. Cremer, K. Werdan, A.F.G. Stevenson, K. Lehner, O. Messerschmidt (1981): Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts. J. Cell Physiol. 106, 99-108

M. Cremer, M. Schachner, T. Cremer, W. Schmidt, T. Voigtländer (1981): Demonstration of astrocytes in cultured amniotic fluid cells of three cases with neural tube defect. Hum. Genet. 56, 365-370

M. Cremer, I. Treiss, T. Cremer, D. Hager, W.W. Franke (1981): Characterization of cells of amniotic fluids by immunological identification of intermediate-sized filaments. Presence of cells of different tissue origin. Hum. Genet. 59, 373-379

T. Cremer, C. Cremer, H. Baumann, E.-K. Luedtke, K. Sperling, V. Teuber, C. Zorn (1982): Rabl's model of interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-uv-microbeam experiments. Hum. Genet. 60, 46-56

T.B.L. Kirkwood, T. Cremer (1982): Cytogerontology since 1881. A reappraisal of August Weismann and a review of modern progress. Hum. Genet. 60, 101-121

C. Cremer, T. Cremer, J.W. Gray (1982): Induction of chromosome damage by ultraviolet light and caffeine. Correlation of cytogenetic evaluation and flow karyotype. Cytometry 2, 287-290

T. Cremer, C. Cremer, T. Schneider, H. Baumann, L. Hens and M. Kirsch-Volders (1982): Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-uv-microirradiation experiments. Hum. Genet. 62, 201-209

C. Cremer, T. Cremer, L. Hens, H. Baumann, J.J. Cornelis and K. Nakanishi (1983): UV-microirradiation of the Chinese hamster cell nucleus and caffeine posttreatment. Immuno-cytochemical localization of DNA photolesions in cells with partial and generalized chromosome shattering. Mutat. Res. 107, 465-476

B. Ochs, W.W. Franke, R. Moll, C. Grund, M. Cremer, T. Cremer (1983): Epithelial character and morphological diversity of cell cultures from human amniotic fluids examined by immunofluorescence microscopy and gel electrophoresis of cytoskeletal proteins. Differentiation 24, 153-173

L. Hens, H. Baumann, T. Cremer, A. Sutter, J.J. Cornelis, C. Cremer (1983): Immunocytochemical localization of chromatin regions uv-microirradiated in S-phase or anaphase: Evidence for a territorial organization of chromosomes during the cell cycle of cultured Chinese hamster cells. Exp. Cell Res. 149, 257-269

M. Raith, T. Cremer, C. Cremer, G. Speit (1984): Sister chromatid exchange (SCE) induced by laser-uv-microirradiation (l = 257 nm): Correlation between the distribution of photolesions and the distribution of SCEs. In: Sister chromatid exchanges: 25 years of experimental research ( R.R. Tice, A. Hollaender, eds), Plenum Press, New York, pp. 181-197

T. Cremer, H. Baumann, K. Nakanishi, C. Cremer (1984): Correlation between interphase and metaphase chromosome arrangements as studied by laser-uv-microbeam experiments. Chromosomes today, Vol. 8, pp. 203-212

T. Cremer and C. Cremer (1984): Chromosomenspezifische DNA-Bibliotheken in der Humangenetik. In: Molekular- und Zellbiologie (N. Blin, M.F. Trendelenburg, E.R. Schmidt, eds), Springer-Verlag, Berlin-Heidelberg-New York-Tokyo, pp. 132-143

G.A. Rappold, T. Cremer, C. Cremer, W. Back, J. Bogenberger, H.J. Cooke (1984): Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes. Hum. Genet. 65, 257-261

G.A. Rappold, T. Cremer, H.D. Hager, K.E. Davies, C.R. Müller, T. Yang (1984): Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes. Hum. Genet. 67, 317-325

G.A. Rappold, H. Hameister, T. Cremer, S. Adolph, B. Henglein, U.-K. Freese, G.M. Lenoir, G.W. Bornkamm (1984): C-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations. EMBO J. 3, 2951-2955

*T. Cremer (1985): Von der Zellenlehre zur Chromosomentheorie. Naturwissenschaftliche Erkenntnis und Theorienwechsel in der frühen Zell- und Vererbungsforschung. Springer-Verlag, Berlin-Heidelberg-New York-Tokyo (384 Seiten)

T. Cremer (1985): August Weismanns Beitrag zur Theorie zellulären Alterns. Freiburger Universitätsblätter, Heft 87/88, 99-106

M. Schardin, T. Cremer, H.D. Hager, M. Lang (1985): Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories. Hum. Genet. 71, 281-287 P.

Devilee, T. Cremer, P. Slagboom, E. Bakker, H.P. Scholl, H.D. Hager, A.F.G. Stevenson, C.G. Cornelisse, P.L. Pearson (1986): Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentromeric heterochromatin of chromosomes 13, 21 and 18. Cytogenet. Cell Genet. 41, 193-201

C. Cremer, T. Cremer (1986): Induction of chromosome shattering by ultraviolet light and caffeine: The influence of different distributions of photolesions. Mutat. Res. 163, 33-40

T. Cremer, J. Landegent, A., Brückner, H.P. Scholl, M. Schardin, H.D. Hager, P. Devilee, P. Pearson, M. van der Ploeg (1986): Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84. Hum. Genet. 74, 346-352

S. Monajembashi, C. Cremer, T. Cremer, J. Wolfrum, K.O. Greulich (1986): Microdissection of human chromosomes by a laser microbeam. Exp. Cell Res. 167, 262-265

P. Loos, T. Cremer, M. Hausmann, A. Jauch, P. Emmerich, W. Schlegel, C. Cremer (1987): Distances between two chromosomes in interphase nuclei as determined with digitized image analysis. In: Clinical Cytometry and Histometry (G. Burger, J.S. Ploem, K. Goerttler, eds). Academic Press, London, S. 285-287

U. Blochmann, G. Dudin, M. Hausmann, H.J. Bühring, T. Cremer, C. Cremer (1987): In situ hybridization of chromosomes with biotinylated DNA after 1g sedimentation. Ann. Univ. Sarav. Med.-Suppl. 7: 32-35

T. Cremer, P. Emmerich, P. Lichter (1987): Gibt es eine zelltypspezifische Anordnung des Chromatins in Säugerzellkernen? Argumente von Ungläubigen, Agnostikern und Gläubigen. Ann. Univ. Sarav. Med.-Suppl. 7, 67-71

G. Dudin, T. Cremer, M. Schardin, M. Hausmann, F. Bier, C. Cremer (1987): A method for nucleic acid hybridization in suspension. Hum. Genet. 76, 290-292

R.H. Singer, J.B. Lawrence, G.L. Langevin, R.N. Rashtchian, C.A. Villnave, T. Cremer, D. Tesin, L. Manuelidis, D.C. Ward (1987): Double labelling in situ hybridization using non-isotopic and isotopic detection. Acta Histochem. Cytochem. 20, 589-599

D.C. Ward, P. Lichter, T. Cremer, N. Guttman-Bass, R. Kandpal, S.M. Weissman, L. Manuelidis (1988): Detection and affinity purification of human DNA sequences using non-isotopically labeled nucleic acid probes. In: Clinical Laboratory Molecular Analysis: Future perspectives. Scripps Clinic and Research Foundation, San Diego, pp. 9-13

T. Cremer, D. Tesin, A.H.N. Hopman, L. Manuelidis (1988): Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes. Exp. Cell Res. 176, 199-220

G. Dudin, E.W. Steegmayer, P. Vogt, H. Schnitzer, E. Diaz, K.E. Howell, T. Cremer, C. Cremer (1988): Sorting of chromosomes by magnetic separation. Hum. Genet. 80, 111-116

P. Lichter, T. Cremer, J. Borden, L. Manuelidis, D.C. Ward (1988): Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA-libraries. Hum.Genet. 80, 224-234

T. Cremer, P. Lichter, J. Borden, D.C. Ward, L. Manuelidis (1988): Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome specific library probes. Hum. Genet. 80, 235-246

P. Lichter, T. Cremer, C.C. Tang, P.C. Watkins, L. Manuelidis, D.C. Ward (1988): Rapid detection of human chromosome 21 aberrations by in situ hybridization. Proc. Natl. Acad. Sci. USA 85, 9664-9668

T. Cremer, C. Cremer (1988): Centennial of Wilhelm Waldeyer's introduction of the term "chromosome" in 1888. Cytogenet. Cell Genet. 48, 66-67

P. Emmerich, P. Loos, A. Jauch, A.H.N. Hopman, J. Wiegant, M. Higgins, B.N. White, M. van der Ploeg, C. Cremer, T. Cremer (1989): Double in situ hybridization in combination with digital image analysis. A new approach to study interphase chromosome topography. Exp. Cell Res. 181, 126-140

P. Emmerich, A. Jauch, M.-C. Hofmann, T. Cremer, H. Walt (1989): Interphase cytogenetics in paraffin embedded sections from human testicular germ cell tumor xenografts and in corresponding cultured cells. Lab. Invest. 61, 235-242

H. Walt, P. Emmerich, T. Cremer, M.-C. Hofmann, F. Bannwart (1989): Supernumerary chromosome 1 in interphase nuclei of atypical germ cells in paraffin-embedded human seminiferous tubules. Lab. Invest. 61, 527-531

*C. Cremer, M. Hausmann, E. Diaz, J. Hetzel, J.A. Aten, T. Cremer (1989): Chromosome aberration detection with hybridized DNA probes: digital image analysis and slit scan flow cytometry. In: Automation of Cytogenetics - Advances in Systems and Techniques (C. Lundsteen, J. Piper, eds), Springer Verlag, Berlin, Heidelberg, New York, pp. 123-132

A. Jauch, H. Walt, P. Emmerich, C. Sigg, T. Cremer (1989): Aneuploid premeiotic germ cells in semen from patients with fertility problems and testis tumors detected by interphase cytogenetics. IV International Congress of Andrology. Serono Symposia Reviews. Suppl. 1 (M. Serio, ed.) Ares Serono Symposia. Rome, S. 301

T. Cremer, S. Popp, P. Emmerich, P. Lichter, C. Cremer (1990): Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization. Cytometry 11, 110-118

D.C. Ward, P. Lichter, T. Cremer, J. Borden, L. Manuelidis (1990): Human chromosome specific probes for the analysis of genetic and neoplastic disease. In: Automation and new technology in the clinical laboratory (K. Okuka, ed), Blackwell Scientific Publications, S. 145-150

R.V. Kolluri, L. Manuelidis, T. Cremer, S. Sait, S. Gezer, A. Raza (1990): Detection of monosomy 7 in interphase cells of patients with myeloid disorders. Am. J. Hematology 33, 117-122

S. Popp, H.P. Scholl, P. Loos, A. Jauch, E. Stelzer, C. Cremer, T. Cremer (1990): Distribution of chromosome 18 and X centric heterochromatin in the interphase nucleus of cultured human cells. Exp. Cell Res. 189, 1-12

Jauch, C. Daumer, P. Lichter, J. Murken, T. Schroeder-Kurth, T. Cremer (1990): Chromosomal in situ suppression hybridization of human gonosomes and autosomes and its use in clinical cytogenetics. Hum. Genet. 85, 145 – 150

J. Wienberg, A. Jauch, R. Stanyon, T. Cremer (1990): Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization. Genomics 8, 341-350

P. Lichter, A. Jauch, T. Cremer, D.C. Ward (1990): Detection of Down syndrome by in situ hybridization with chromosome 21 specific DNA probes. In: The 21st chromosome and Down syndrome (D. Patterson et al., eds.), Wiley-Liss, New York,S. 69-78

Lengauer, A. Eckelt, A. Weith, N. Endlich, N. Ponelies, P. Lichter, K.O. Greulich, T. Cremer (1991): Selective staining of defined chromosomal regions by in situ suppression hybridization of libraries from laser-microdissected chromosomes. Cytogenet. Cell Genet. 56, 27-30

T. Ried, V. Mahler, P. Vogt, L. Blonden, G.J.B. van Ommen, T. Cremer, M. Cremer (1990): Carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy (DMD/BMD)-locus. Hum. Genet. 85, 581-586

S. Popp, B. Remm, M. Hausmann, H. Lührs, G. van Kaick, T. Cremer, C. Cremer (1990): Towards a cumulative biological dosimeter based on chromosome painting and digital image analysis. Kerntechnik 55, 204-210

Lengauer, H. Riethman, T. Cremer (1990) Painting of human chromosomes generated from hybrid cell lines by PCR with Alu and L1 primers. Hum. Genet. 86, 1-6

P. Lichter, A. L. Boyle, T. Cremer, D. C. Ward (1991) Analysis of genes and chromosomes by non-isotopic in situ hybridization. Genet. Anal. Techn. Appl., 8, 24-35

S. Popp, A. Jauch, J.Y. Qiu, B. Smialek, T. Cremer, R. Becher. (1991). Translocation t(8;21) in acute lymphocytic leukemia delineated by chromosomal in situ suppression hybridization. Cancer Genet. Cytogenet. 57, 103-107

T. Cremer, B. Remm, I. Kharboush, A. Jauch, J. Wienberg, E. Stelzer, C. Cremer (1991) Non isotopic in situ hybridization and digital image analysis of chromosomes in mitotic and interphase cells. In: Proceedings of the First European Conference on Biomedical Engineering, Nice, February 1991, RBM 13, 50-54

Walt H., Emmerich, P., Jauch A., Cremer T. (1990) Interphase cytogenetics of precancerous and neoplastic human testicular germ cells. In: Advances in analytical cellular pathology (G. Burger, M. Oberholzer, G.P. Vooijs eds.) Excerpta Medica, Int. Congress Series, S. 71-72, Elsevier Science Publishers B.V. (Biomedical Division) Amsterdam, New York, Oxford

Lengauer C., Lüdecke H.-J., Wienberg J., Cremer T., Horsthemke B. (1991) Comparative chromosome band mapping in primates by in situ suppression hybridization of band specific DNA microlibraries. Hum. Evol. 6, 67-71

Ried T., Lengauer C., Cremer T., Wiegant J., Raap A.K., van der Ploeg M., Groitl P., Lipp M. (1992) Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple color fluorescence in situ hybridization. Genes, Chromosomes and Cancer 4, 69-74

Tiainen M., Popp S., Parlier V., Emmerich P., Jotterand Bellomo M., Ruutu T., Cremer T., Knuutila S. (1992) Chromosomal in situ suppression hybridization of immunologically classified mitotic cells in hematological malignancies. Genes, Chromosomes and Cancer 4, 135-140

Lichter P. and Cremer T. (1992) Chromosome analysis by non-isotopic in situ hybridization. In: Human Cytogenetics (Vol I): A practical approach. DE Rooney & Czepulkowski, eds. 2nd edition. IRL Press, 157-192

Wienberg J., Stanyon R., Jauch A., Cremer T. (1992) Homologies in human and macaca fuscata chromosomes revealed by in situ suppression hybridization with human chromosome specific DNA libraries. Chromosoma 101, 265-270

Dunham I., Lengauer C., Cremer T., Featherstone T. (1992) Rapid generation of chromosome specific alphoid DNA probes using the polymerase chain reaction. Hum. Genet. 88, 457-462

Popp S., Cremer T. (1992) A biological dosimeter based on translocation scoring after multicolor CISS hybridization of chromosomal subsets. J. Radiat. Res. 33 (Supplement), 61-70

Stanyon R., Wienberg J., Romagno D., Bigoni F., Jauch A., Cremer T. (1992) Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation in Gorilla gorilla. Am. J. Phys. Anthropol. 88, 245-250

Jauch A., Wienberg J., Stanyon R., Arnold N., Tofanelli S., Ishida T., Cremer T. (1992) Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting. Proc. Natl. Acad. Sci. USA 89, 8611-8615

Lengauer C., Green E., Cremer T. (1992). Fluorescence in situ hybridization of YAC clones after inter-Alu-PCR amplification. Genomics, 13, 826-828

Lengauer C., Riethman H., Speicher M., Taniwaki M., Konecki D., Green D., Becher R., Olson M., Cremer T. (1992). Metaphase and interphase cytogenetics with Alu-PCR amplified YAC clones containing the BCR-gene and the protooncogenes c-raf-1, c-fms, c-erbB-2. Cancer Research 52, 2590-2596

Cremer C., Cremer T. (1992). Analysis of chromosomes in molecular tumor and radiation cytogenetics: Approaches, applications, perspectives. Eur. J. Histochem. 36, 15-25

Bischoff A., Schmidt J., Kharboush I., Stelzer E., Cremer T, Cremer C. (1993). Differences of size and shape of active and inactive X-chromosome domains in human amniotic fluid cell nuclei. Microscopy Research and Technique 25, 68-77

Joos S, Scherthan H, Speicher MR, Schlegel J., Cremer T, Lichter P. (1993). Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe. Hum. Genet. 90, 584-589

du Manoir S, Speicher MR, Joos S, Schroeck E, Popp S, Döhner H., Kovacs G, Robert-Nicoud M, Lichter P, Cremer T (1993). Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum. Genet. 90, 590-610

Lengauer C, Speicher MR, Popp S, Jauch A, Taniwaki M, Nagaraja R, Riethman HC, Donis-Keller H, D'Urso M, Schlessinger D, Cremer T (1993). Chromosomal bar codes produced by multicolor fluorescence in situ hybridization with multiple YAC clones and whole chromosome painting probes. Hum Mol Genet 2, 505-512

Zirbel RM, Mathieu UR, Kurz A, Cremer T, Lichter P (1993) Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chromosome Research 1, 93-106

Taniwaki M, Speicher MR, Lengauer C, Jauch A, Popp S, Cremer T (1993) Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two color fluorescence in situ hybridization. Cancer Genet Cell Genet 70, 99-102

Popp S, Jauch A, Schindler D, Speicher MR, Lengauer C, Donis-Keller H, Riethman HC, Cremer T (1993). A strategy for the characterization of minute chromosome rearrangements using multiple fluorescence in situ hybridization with chromosome- specific DNA libraries and YAC clones. Hum Genet 92, 527-532

Ried T, Lengauer C, Lipp M, Fischer C, Cremer T, Ward DC (1993) Evaluation of the utility of interphase cytogenetics to detect residual cells with a malignant genotype in mixed cell populations: a Burkitt lymphoma model. DNA and Cell Biology 12, 637-643

Cremer C, Hausmann M, Popp S, Cremer T (1993) Analyse von Strahlenschäden in menschlichen Metaphasechromosomen nach Fluoreszenz in situ Hybridisierung. In: Zytogenetische Methoden im Rahmen des Populationsmonitorings (D. Arndt, G. Obe, ed.)bga-Schriften 3/93, pp. 27-32, MMV Medizin Verlag München Wessman

M, Popp S, Ruutu T, Volin L, Cremer T, Knuutila S (1993) Detection of residual host cells after bone marrow transplantation using non-isotopic in situ hybridization and karyotype analysis. Bone Marrow Transplantation 11, 279-284

Cremer T, Lichter P, Popp S, Schröck E, Jauch A, du Manoir S, Joos S, Lengauer C, Scherthan H, Ried T, Speicher MR (1993) Detection of genetic imbalances in tumor genomes by fluorescence in situ hybridization with tumor genomic DNA and subregional DNA probes. In: Chromosomal Alterations, Origin and Significance (G. Obe and A.T. Natarajan, eds.), 42-49, Springer Verlag Berlin, Heidelberg, New York

Cremer T, Kurz A, Zirbel R, Dietzel S, Rinke B, Schröck E, Speicher MR, Mathieu U, Jauch A, Emmerich P, Scherthan H., Ried T, Cremer C, Lichter P (1993) The role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp Quant Biol. 58, 777-792

Speicher MR, du Manoir S, Schröck E, Holtgreve-Grez H, Schoell B, Lengauer C, Cremer T, Ried T (1993) Molecular cytogenetic analysis of formalin fixed, paraffin embedded solid tumors by comparative genomic hybridization after universal DNA amplification. Hum Mol Genet. 2, 1907-1914

Tocharoentanaphol C, Cremer M, Schröck E, Kilian K, Cremer T, Ried T (1994) Multicolor fluorescence in situ hybridization on metaphase chromosomes and interphase Halo-preparations using cosmid and YAC clones for the simultaneous high resolution mapping of deletions in the dystrophin gene. Hum Genet, 93, 229-235

Scherthan H., Cremer T., Arnason U., Weier H.-U., Lima-de-Faria A., Frönicke L (1994) Comparative chromosome painting discloses homologous segements in evolutionary distant mammalian species. Nature Genetics 6, 342-347

Scherthan H, Cremer T (1994) Nonisotopic in situ hybridization in paraffin-embedded tissue sections. In: Methods in Molecular Genetics, Vol. 5, Gene and Chromosome Analysis Part C (K.W. Adolph, ed.), 223 - 238, Academic Press, San Diego

Lengauer C, Speicher MR, Cremer T (1994) FISH of Alu-PCR amplified YAC clones and applications in tumor cytogenetics. In: Methods in Molecular Biology, Vol. 33, In situ hybridization protocols (K.H.A. Choo ed.), 85-94, The Humana Press, Totowa, New Jersey Lengauer

C, Dunham I, Featherstone T, Cremer T (1994) Generation of alphoid DNA probes for fluorescence in situ hybridization using the polymerase chain reaction. In: Methods in Molecular Biology, Vol. 33, In situ hybridization protocols (K.H.A. Choo ed.), 51-61, The Humana Press, Totowa, New Jersey

Schröck E, Thiel, Lozonova T, du Manoir S, Meffert MC, Jauch A, Speicher MR, Nürnberg P, Vogel S, Jänisch W, Donis-Keller H, Ried T, Witkowski R, Cremer T (1994) Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and non-random chromosomal gains and losses. Am J Path 144, 1203-1218

Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, du Manoir S, Cremer T (1994) Comparative genomic hybridization reveals multiple DNA gains and losses in small cell lung carcinomas. Cancer Research 54, 1801-1806

Speicher MR, Prescher G, du Manoir S, Jauch A, Horsthemke B, Bornfeld N, Becher R, Cremer T (1994) Chromosomal gains and losses in uveal melanomas by comparative genomic hybridization. Cancer Research 54, 3817-3823

Speicher MR, Schoell B, du Manoir S, Schröck E, Ried T, Cremer T, Störkel S, Kovacs A, Kovacs G (1994) Loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 in chromophobe renal cell carcinomas. Am J Path 145, 356-364

Wienberg T, Jauch A, Lüdecke H-J, Senger G, Horsthemke B, Claussen U, Cremer T, Arnold N, Lengauer C (1994) The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary. Chromosome Research 2, 405-410

Eils R, Dietzel S, Bertin E, Schröck E, Usson Y, Robert-Nicoud M, Cremer T, Cremer C (1994) 3D-Voronoi Diagramme zur quantitativen Bildanalyse in der Interphase-Cytogenetik. In: Mustererkennung 1994 (Hrsg W.G. Kropatsch und H. Bischof), InformatikXPress 5, 207-219, Springer Verlag

Du Manoir S, Schröck E, Bentz M, Speicher MR, Joos S, Ried T, Lichter P, Cremer T (1995) Quantitative analysis of comparative genomic hybridization. Cytometry 19, 27-41

Rinke B, Bischoff A, Meffert M-C, Scharschmidt R, Hausmann M, Stelzer EHK, Cremer T, Cremer C (1995) Volume ratios of painted chromosome territories 5, 7 and X in female human cell nuclei studied with confocal laser microscopy and the Cavalieri estimator. Bioimaging 3, 1-11

Eils R, Bertin E, Saracoglu K, Rinke B, Schröck E, Parazza F, Usson Y, Robert-Nicoud M, Stelzer EHK, Chassery J-M, Cremer T, Cremer C (1995) Application of confocal laser microscopy and three-dimensional Voronoi diagrams for volume and surface estimates of interphase chromosomes. J Microsc 177, 150-161

Eils R, Saracoglu K, Münkel C, Imhoff J, Sätzler K, Bertin E, Dietzel S, Schröck E, Ried T, Cremer T, Cremer C (1995) Three-dimensional imaging approaches and Monte Carlo simulations: developments of tools to study the morphology and distribution of chromosome territories and subchromosomal targets in human cell nuclei. Zoological Studies 34, Suppl. 1, 7-11

Münkel C, Eils R, Imhoff J, Dietzel S, Cremer C, Cremer T (1995) Simulation of the distribution of chromosome territories in interphase nuclei under geometrical constraints. Bioimaging 3, 108-120

Dietzel S, Weilandt E, Eils R, Münkel C, Cremer C, Cremer T (1995) Three-dimensional distribution of centromeric or paracentromeric heterochromatin of chromosomes 1, 7, 15, and 17 in human lymphocyte nuclei studied with light microscopic axial tomography. Bioimaging 3, 121-133

Cremer T, Jauch A, Ried T, Schröck E, Cremer M, Speicher MR. (1995) Fluoreszenz in situ Hybridisierung (FISH) in der Medizinischen Genetik und Tumorzytogenetik. Deutsches Ärzteblatt 92, Heft 22,A1593-A1601

Cremer T, Dietzel S, Eils R, Lichter P, Cremer C (1995) Chromosome territories, nuclear matrix filaments and interchromatin channels: a topological view on nuclear architecture and function. Kew Chromosome Conference IV (Eds P.E. Brandham and M.D. Bennett), pp. 63-81, Royal Botanic Gardens, Kew.

Speicher MR, Jauch A, Walt H, du Manoir S, Ried T, Jochum W, Sulser T, Cremer T (1995) Correlation of microsocopic phenotype with genotype in a formalin-fixed, paraffine-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics. Am J Path 146, 1332-1340

Ried T, Just KE, Holtgreve-Grez H., du Manoir S, Speicher MR, Schröck E, Latham C, Blegen H, Zetterberg A, Cremer T, Auer G (1995) Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and aneuploid carcinomas. Cancer Research 55, 5415-5423

Cremer C, Cremer T, Popp S, Durm M, Hausmann M (1995) Moderne Chromosomentests zur schnellen Detektion von Aberrationen in der biologischen Dosimetrie. Deutsches Ärzteblatt 92, A: 1922-1928

Weber RG, Sommer C, Albert FK, Kiessling M, Cremer T (1996) Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization. Lab Invest 74, 108-119

Schröck E, Blume C, Meffert M-C, du Manoir S, Bersch W, Kiessling M, Lozanowa T, Thiel G, Witkowski R, Ried T, Cremer T (1996) Recurrent gain of chromosme arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization. Genes, Chromsomes & Cancer 15, 199-205

Tanaka K, Popp S, Fischer C, van Kaick G, Kamada N, Cremer T, Cremer C (1996) Chromosome aberration analysis in atomic bomb survivors and Thorotrast patients using two- and three-color chromosome painting of chromosomal subsets. Int. J. Radiat. Biol. 70, 95-108

Cremer C, Münkel C, Granzow M, Jauch A, Dietzel S, Eils R, Guan XY, Meltzer PS, Trent JM, Langowski J, Cremer T (1996) Nuclear architecture and the induction of chromosomal aberrations. Mutat. Res. Rev Genet Toxicol 366/2, 97-116

Scherthan H, Weich S, Schwegler H, Härle M, Heyting C, Cremer T (1996) Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J Cell Biol 134, 1109-1125

Weber, RG, Sabel, M, Reifenberger J, Sommer C, Oberstraß J, Reifenberger G, Kiessling M, Cremer T (1996) Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 13, 983-994

Kurz A, Lampel S, Nickolenko J, Bradl J, Benner A, Zirbel R, Cremer T, Lichter P (1996) Localization of active and inactive genes in the periphery of chromosome territories. J. Cell Biol 135, 1195-1205

Eils R, Dietzel S, Bertin E, Schröck E, Speicher MR, Ried T, Robert-Nicoud M, Cremer C, Cremer T (1996) Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X-chromosome territories have similar volumes but differ in surface and shape. J Cell Biol 135, 1427-1440

Giollant-M, Bertrand S, Verrelle P, Tchirkov A, du Manoir S, Ried T, Mornex F, Dore JF, Cremer T, Malet P (1996) Characterization of double minute chromosomes DNA content in a human high grade astrocytoma cell line by using comparative genomic hybridization and fluorescence in situ hybridization. Hum Genet 98, 265-270

Gronwald, J, Störkel, S, Holtgreve-Grez, H, Hadlacek, P, Brinkschmidt, C, Jauch, A, Lubinski, J, Cremer, T (1997) Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: Importance of 1q copy number changes in metastatic events. Cancer Research 57, 481-487

Kraus J, Weber RG, Cremer M, Seebacher T, Fischer C, Schurra C, Jauch A, Lichter P, Bensimon A, Cremer T (1997) High-resolution comparative hybridization to combed DNA fibers. Hum Genet 99, 374-380

Craig JM, Kraus J, Cremer T (1997) Removal of repetitive sequences from FISH probes using PCR-assisted affinity chromatography. Hum Genet 100, 472-476

Petersen I, Bujard M, Petersen S, Wolf G, Goeze A, Schwendel A, Langreck H, Gellert K, Reichel M, Just K, du Manoir S, Cremer T, Dietel M, Ried T (1997) Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Research 57, 2331-2335

Boukamp P, Popp S, Altmeyer S, Hulsen A, Fasching C, Cremer T, Fusenig NE (1997) Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT. Genes Chromosomes Cancer 19, 201-14

Van Roy N, Jauch A, Van Gele M, Laureys G, Versteeg R, De Paepe A; Cremer T, Speleman F (1997) Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines. Cancer Genet Cytogenet. 97, 135-42

Solinas-Toldo S, Lampel S, Stilgenbauer S, Nickolenko J, Benner A, Döhner H, Cremer T, Lichter P (1997) Matrix-based comparative genomic hybridization: biochips to screen for genomic imbalances. Genes, Chromosomes and Cancer 20, 399-407

Cremer T (1998) Menschliche Genomanalyse: Auf dem Weg zu einer prädiktiven Medizin? In: Bauer AW (Hrsg.): Medizinische Ethik am Beginn des 21. Jahrhunderts. Theoretische Konzepte - Klinische Probleme - Ärztliches Handeln. (Medizin im Dialog.) J.A. Barth, Heidelberg, Leipzig, 38-51.

Dietzel S, Jauch A, Kienle D, Qu G, Holtgreve-Grez H, Eils R, Münkel C, Bittner M, Meltzer PS, Trent JM, Cremer T. (1998) Separate and variably shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei. Chromosome Research 6, 25-33

Dietzel S, Eils R, Sätzler K, Bornfleth H, Jauch A, Cremer C, Cremer T. (1998) Evidence against a looped structure of the inactive human X-chromosome territory. Exp Cell Res 240, 187-196

Zink D, Cremer T, Saffrich R, Fischer R, Trendelenburg MF, Ansorge W, Stelzer EHK. (1998) Structure and dynamics of human interphase chromosome territories in vivo.. Hum. Genet. 102:241-251

Zink D, Cremer T (1998) Chromosome dynamics in nuclei of living cells. Curr Biol 8, 321-324 Visser AE, Eils R, Jauch A, Little G, Bakker PJM, Cremer T, Aten JA (1998) Spatial Distributions of Early and Late Replicating Chromatin in Interphase Chromosome Territories. Exp Cell Res. 243: 398-407.

Scherthan H, Eils R, Trelles-Sticken E, Dietzel S, Cremer T, Walt H, Jauch A. (1998) Aspects of three-dimensional chromosome reorganization during the onset of human male meiotic prophase. J Cell Science 111, 2337-2351

Cremer T (1998) Menschliche Genomanalyse: Auf dem Weg zu einer prädiktiven Medizin? In: Medizinische Ethik am Beginn des 21. Jahrhunderts (A. W. Bauer, Hrsg.) S. 38-51. Johann Ambrosius Barth Verlag, Heidelberg, Leipzig.

Kreth G, Münkel C, Langowski J, Cremer T, Cremer C (1998) Chromatin structure and chromosome aberrations: modeling of damage induced by isotropic and localized irradiation. Mutat Res 404: 77-88

Cremer T, Speicher M, Zink D (1998) Vielfarbige Chromosomen. Neue Wege zur Analyse des menschlichen Genoms. Einsichten - Forschung an der Ludwig-Maximilians-Universität München. Heft 1998/2, 10-13

Zink D, Bornfleth H, Visser A, Cremer C, Cremer T (1999) Organization of early and late replicating DNA in human chromosome territories. Exp Cell Res 247, 176-188

Dietzel S, Schiebel K, Little G, Edelmann P, Rappold GA, Eils R, Cremer C, Cremer T. (1999) The 3D-positioning of ANT2 and ANT3 genes within female X chromosome territories correlates with gene activity, Exp Cell Res 252, 363-375

Münkel C, Eils R, Dietzel S, Zink, D, Mehring C, Wedemann G, Cremer T, Langowski J. (1999) Compartmentalization of interphase chromosomes observed in simulation and experiment. J Mol Biol 285, 1053-1065

Gronwald J, Baur AS, Holtgreve-Grez H, Jauch A, Mosimann F, Jichlinski P, Wauters J-P, Cremer T, Guillou L (1999) Chromosomal abnormalities in renal cell neoplasms associated with acquired renal cystic disease. A series studied by comparative genomic hybridization and fluorescence in situ hybridization. J Pathol 187, 308-312

Cremer C, Edelmann P, Esa A, Bornfleth H, Schneider B, Bradl J, Rinke B, Trakthtenbrot L, Dietzel S, Hausmann M, Cremer T (1999) Spektrale Präzisionsdistanzmikroskopie in der Genomforschung. Z. Med. Phys. 9, 14-20

Bolzer A, Craig JM, Cremer T, Speicher MR (1999) A complete set of repeat-depleted PCR-amplifiable, human chromosome-specific painting probes. Cytogenet Cell Genet 84, 233-240

Schermelleh L, Thalhammer S, Heckl W, Pösl H, Cremer T, Schütze K, Cremer M (1999) Laser microdissection and laser pressure catapulting for the generation of chromosome-specific paint probes. BioTechniques 27, 362-367

Bornfleth H, Edelmann P, Zink D, Cremer T, Cremer C (1999) Quantitative motion analysis of sub-chromosomal foci in vivo in four-dimensional microscopic images, Biophysical Journal 77, 2871-2886.

Sadoni, N., Langer, S., Fauth, C., Bernardi, G., Cremer, T., Turner, B.M., Zink, D. (1999) Nuclear organization of mammalian genomes: polar chromosome territories built up functionally distinct higher order compartments, J Cell Biol 146, 1211-1226.

Gronwald, J., Hadaczek, P., Störkel, S., Holtgreve-Grez, H., Rabitts, P., Cremer, T., Lubinski, J. (1999) Molecular evidence for derivation of metastatic cells from minor subclones of primary clear renal cell carcinomas. Cancer Detection and Prevention 23, 479-484.