Anthropology and Human Genetics
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Publications

2016

Enard, W. (2016). The Molecular Basis of Human Brain Evolution. Current Biology Volume 20, Issue 20: pR1109–R1117. http://www.cell.com/current-biology/abstract/S0960-9822(16)31081-8

Ziegenhain, C., Parekh, S., Vieth, B., Smets, M., Leonhardt, H., Hellmann, I., and Enard, W. (2016). Comparative analysis of single-cell RNA-sequencing methods. http://biorxiv.org/content/early/2016/06/29/035758

Parekh, S., Ziegenhain, C., Vieth, B., Enard, W., and Hellmann, I. (2016). The impact of amplification on differential expression analyses by RNA-seq. Scientific Reports 6, Article number:25533. http://www.nature.com/articles/srep25533

2015

Hammerschmidt, K., Schreiweis, C., Minge, C., Paabo, S., Fischer, J., and Enard, W. (2015). A humanized version of Foxp2 does not affect ultrasonic vocalization in adult mice. Genes, brain, and behavior 14, 583-590. http://www.ncbi.nlm.nih.gov/pubmed/26250064

Enard, W. (2015). Human evolution: enhancing the brain. Curr Biol 25, R421-423. http://www.ncbi.nlm.nih.gov/pubmed/25989083

2014

Enard, W. (2014). Comparative genomics of brain size evolution. Frontiers in Human Neurscience 8:345. doi: 10.3389/fnhum.2014.00345

Schreiweis, C., Bornschein, U., Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C.A., Puliyadi, R., Groszer, M., Fisher, S.E., Mundry, R., Winter, C., Hevers, W., Paabo, S., Enard*, W., and Graybiel*, A.M. (2014). Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proc Natl Acad Sci USA. http://www.ncbi.nlm.nih.gov/pubmed/25225386

Enard, W. (2014). Comparative genomics of brain size evolution. Front. Hum. Neursci. 8:345, doi:10.3389/fnhum.2014.00345.

Wunderlich, S., Kircher, M., Vieth, B., Haase, A., Merkert, S., Beier, J., Göhring, G., Glage, S., Schambach, A., Curnow, WE.C., Pääbo, S., Martin, U., and Enard, W. (2014). Primate iPS cells as tools for evolutionary analyses. Stem Cell Research, http://dx.doi.org/10.1016/j.scr.2014.02.001.

2012

Enard, W. (2012). Functional primate genomics-leveraging the medical potential. J Mol Med (Berl) 90, 471-480.

Clovis, Y.M., Enard, W., Marinaro, F., Huttner, W.B., and De Pietri Tonelli, D. (2012). Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons. Development 139, 3332-3342, http://www.ncbi.nlm.nih.gov/pubmed/22874921.

Enard, W. (2012). Functional primate genomics--leveraging the medical potential. J Mol Med (Berl) 90, 471-480, http://www.ncbi.nlm.nih.gov/pubmed/22555407.

2011

Enard, W. (2011). FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution. Curr Opin Neurobiol 21, 415-424, http://www.ncbi.nlm.nih.gov/pubmed/21592779.

2010

Staubert, C., Boselt, I., Bohnekamp, J., Rompler, H., Enard, W., and Schoneberg, T. (2010). Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS One 5, e11133, http://www.ncbi.nlm.nih.gov/pubmed/20559446

2009

Enard, W., et al. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971.

Ptak, S.E., Enard, W., Wiebe, V., Hellmann, I., Krause, J., Lachmann, M., and Paabo, S. (2009). Linkage disequilibrium extends across putative selected sites in FOXP2. Mol Biol Evol 26, 2181-2184, http://www.ncbi.nlm.nih.gov/pubmed/19608635

Enard, W., Gehre, S., Hammerschmidt, K., Holter, S.M., Blass, T., Somel, M., . . . Paabo, S. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971, http://www.ncbi.nlm.nih.gov/pubmed/19490899.

2007

Krause, J., Lalueza-Fox, C., Orlando, L., Enard, W., Green, R.E., Burbano, H.A., . . . Paabo, S. (2007). The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol 17, 1908-1912, http://www.ncbi.nlm.nih.gov/pubmed/17949978

Timpson, N., Heron, J., Smith, G.D., and Enard, W. (2007). Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM. Science 317, 1036; author reply 1036, http://www.ncbi.nlm.nih.gov/pubmed/17717170.

Prufer, K., Muetzel, B., Do, H.H., Weiss, G., Khaitovich, P., Rahm, E., . . . Enard, W. (2007). FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics 8, 41, http://www.ncbi.nlm.nih.gov/pubmed/17284313.

2006

Khaitovich, P., Enard, W., Lachmann, M., and Paabo, S. (2006a). Evolution of primate gene expression. Nat Rev Genet 7, 693-702, http://www.ncbi.nlm.nih.gov/pubmed/16921347

Khaitovich, P., Tang, K., Franz, H., Kelso, J., Hellmann, I., Enard, W., . . . Paabo, S. (2006b). Positive selection on gene expression in the human brain. Curr Biol 16, R356-358, http://www.ncbi.nlm.nih.gov/pubmed/16618540.

Fish, J.L., Kosodo, Y., Enard, W., Paabo, S., and Huttner, W.B. (2006). Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A 103, 10438-10443, http://www.ncbi.nlm.nih.gov/pubmed/16798874.

2005

Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiss, G., Lachmann, M., and Paabo, S. (2005). Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science 309, 1850-1854.

Woods, C.G., Bond, J., and Enard, W. (2005). Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet 76, 717-728, http://www.ncbi.nlm.nih.gov/pubmed/15806441

Heissig, F., Krause, J., Bryk, J., Khaitovich, P., Enard, W., and Paabo, S. (2005). Functional analysis of human and chimpanzee promoters. Genome Biol 6, R57, http://www.ncbi.nlm.nih.gov/pubmed/15998446.

2004

Khaitovich, P., Weiss, G., Lachmann, M., Hellmann, I., Enard, W., Muetzel, B., . . . Paabo, S. (2004a). A neutral model of transcriptome evolution. PLoS Biol 2, E132, http://www.ncbi.nlm.nih.gov/pubmed/15138501.

Enard, W., Fassbender, A., Model, F., Adorjan, P., Paabo, S., and Olek, A. (2004). Differences in DNA methylation patterns between humans and chimpanzees. Curr Biol 14, R148-149, http://www.ncbi.nlm.nih.gov/pubmed/15027464

Enard, W., and Paabo, S. (2004). Comparative primate genomics. Annu Rev Genomics Hum Genet 5, 351-378, http://www.ncbi.nlm.nih.gov/pubmed/15485353.

2003

Hellmann, I., Zollner, S., Enard, W., Ebersberger, I., Nickel, B., and Paabo, S. (2003a). Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res 13, 831-837, http://www.ncbi.nlm.nih.gov/pubmed/12727903.

2002

Enard, W., Przeworski, M., Fisher, S.E., Lai, C.S., Wiebe, V., Kitano, T., . . . Paabo, S. (2002a). Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418, 869-872, http://www.ncbi.nlm.nih.gov/pubmed/12192408.

Enard, W., Khaitovich, P., Klose, J., Zollner, S., Heissig, F., Giavalisco, P., . . . Paabo, S. (2002b). Intra- and interspecific variation in primate gene expression patterns. Science 296, 340-343, http://www.ncbi.nlm.nih.gov/pubmed/11951044.

2001

Straube, A., Enard, W., Berner, A., Wedlich-Soldner, R., Kahmann, R., and Steinberg, G. (2001). A split motor domain in a cytoplasmic dynein. Embo J 20, 5091-5100, http://www.ncbi.nlm.nih.gov/pubmed/11566874